Developmental Biology Program
The Lorenz Studer Lab
Research
Our laboratory aims at exploiting recent advances in stem cell biology to develop radically new therapies for degenerative disease and cancer. The main focus in the lab is on the biology and application of human embryonic stem (ES) and human induced pluripotent (iPS) cells. Pluripotent stem cells can provide a truly unlimited source for deriving therapeutically relevant cell types for applications in human disease modeling or regenerative medicine.
Research Projects
Featured News
Publications Highlights
Chan YH, Liu Z, Bastard P, Khobrekar N, Hutchison KM, Yamazaki Y, Fan Q, Matuozzo D, Harschnitz O, Kerrouche N, Nakajima K, Amin P, Yatim A, Rinchai D, Chen J, Zhang P, Ciceri G, Chen J, Dobbs K, Belkaya S, Lee D, Gervais A, Aydın K, Kartal A, Hasek ML, Zhao S, Reino EG, Lee YS, Seeleuthner Y, Chaldebas M, Bailey R, Vanhulle C, Lorenzo L, Boucherit S, Rozenberg F, Marr N, Mogensen TH, Aubart M, Cobat A, Dulac O, Emiroglu M, Paludan SR, Abel L, Notarangelo L, Longnecker R, Smith G, Studer L., Casanova JL, Zhang SY. Human TMEFF1 is a restriction factor for herpes simplex virus in the brain. Nature. 2024 Jul 24. doi: 10.1038/s41586-024-07745-x. Online ahead of print. PMID: 39048830
Kim TW, Koo SY, Riessland M, Chaudhry F, Kolisnyk B, Cho HS, Russo MV, Saurat N, Mehta S, Garippa R, Betel D, Studer L. TNF-NF-κB-p53 axis restricts in vivo survival of hPSC-derived dopamine neurons. Cell. 2024 Jul 11;187(14):3671-3689.e23. doi: 10.1016/j.cell.2024.05.030. Epub 2024 Jun 11. PMID: 38866017 Free article.
Saurat N, Minotti AP, Rahman MT, Sikder T, Zhang C, Cornacchia D, Jungverdorben J, Ciceri G, Betel D, Studer L. Genome-wide CRISPR screen identifies neddylation as a regulator of neuronal aging and AD neurodegeneration. Cell Stem Cell. 2024 Aug 1;31(8):1162-1174.e8. doi: 10.1016/j.stem.2024.06.001. Epub 2024 Jun 24. PMID: 38917806 Free article.
de Luzy IR, Lee MK, Mobley WC, Studer L. Lessons from inducible pluripotent stem cell models on neuronal senescence in aging and neurodegeneration. Nat Aging. 2024 Mar;4(3):309-318. doi: 10.1038/s43587-024-00586-3. Epub 2024 Mar 1. PMID: 38429379 Review.
Ciceri G, Baggiolini A, Cho HS, Kshirsagar M, Benito-Kwiecinski S, Walsh RM, Aromolaran KA, Gonzalez-Hernandez AJ, Munguba H, Koo SY, Xu N, Sevilla KJ, Goldstein PA, Levitz J, Leslie CS, Koche RP, Studer L. An epigenetic barrier sets the timing of human neuronal maturation. Nature. 2024 Jan 31. doi: 10.1038/s41586-023-06984-8. Online ahead of print. PMID: 38297124
People
Lorenz Studer, MD
Director, Center for Stem Cell Biology
- The Studer laboratory investigates human stem cells as tools to understand normal and pathological development in the nervous system and to develop cell-based strategies for regenerative medicine.
- MD, Universitat Bern
- studerl@mskcc.org
- Email Address
- 212-639-6126
- Office Phone
Members
- BS, Cornell University
- Cancer Biology
- 212-639-8510
- Lab Phone
- Princeton University
- Connecticut College
- Wellesley College
Lab Alumni
Lab Affiliations
Achievements
- ISSCR Achievement Award (2022)
- Jacob & Louise Gabbay Award in Biotechnology & Medicine (2018)
- Ogawa-Yamanaka Stem Cell Prize, Gladstone Institutes (2017)
- MacArthur Fellow (2015)
- Member, American Society of Clinical Investigation (2014)
Read more
- Annemarie Opprecht Parkinson Award, Annemarie Opprecht Foundation (2012)
- Louise and Allston Boyer Young Investigator in Basic Research, Memorial Sloan Kettering Cancer Center (2005)
Open Positions
To learn more about available postdoctoral opportunities, please visit our Career Center
To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs
Career Opportunities
Get in Touch
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Lab Head Email
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Office Phone
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Office Fax
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Lab Phone
Disclosures
Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.
Lorenz Studer discloses the following relationships and financial interests:
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BlueRock Therapeutics
Intellectual Property Rights; Professional Services and Activities -
DaCapo Brainscience, Inc.
Equity; Professional Services and Activities (Uncompensated) -
Fujifilm Cellular Dynamics, Inc.
Intellectual Property Rights -
Luxa Biotechnology, LLC
Professional Services and Activities
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Roche
Professional Services and Activities -
Rumi Scientific, Inc.
Equity; Professional Services and Activities (Uncompensated) -
Vita Therapeutics, Inc.
Equity; Professional Services and Activities (Uncompensated)
The information published here is a complement to other publicly reported data and is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.
This page and data include information for a specific MSK annual disclosure period (January 1, 2023 through disclosure submission in spring 2024). This data reflects interests that may or may not still exist. This data is updated annually.
Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at ecoi@mskcc.org.