Chemical Biology Program

The Daniel Bachovchin Lab

Research

Daniel Bachovchin
Daniel Bachovchin, PhD
Geoffrey Beene Junior Faculty Chair

The Bachovchin lab uses chemical and cell biology approaches to study important questions in innate immunity. We are particularly interested in characterizing the molecular mechanisms controlling the formation of inflammasomes, key components of the innate immune system that sense intracellular danger signals and trigger pyroptotic cell death. 

Publications Highlights

Chui, A.J*; Okondo, M.C.*; Rao, S.D.*; Gai, K.; Griswold, A.R.; Johnson, D.C.; Ball, D.P.; Taabazuing, C.Y.; Orth, E.L.; Vittimberga, B.A.; Bachovchin, D.A. # “N-terminal degradation activates the Nlrp1b inflammasome.” Science. 2019, 365, 82-85.

Rao, S.D.*; Chen, Q.*; Wang, Q.*; Orth-He, E.L.*; Saoi, M.; Griswold, A.R.; Bhattacharjee, A.; Ball, D.P.; Huang, H.-C.; Chui, A.J.; Covelli, D.J.; You, S.; Cross, J.R.; Bachovchin, D.A. # “M24B aminopeptidase inhibitors selectively activate the CARD8 inflammasome.” Nat Chem Biol. 2022, 18, 565-574.

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People

Daniel Bachovchin

Daniel Bachovchin, PhD

Geoffrey Beene Junior Faculty Chair

  • Chemical biologist Daniel Bachovchin designs selective inhibitors to study enzymes and pathways in cancer and immune system signaling.
  • PhD, The Scripps Research Institute
  • AB, Harvard College
bachovcd@mskcc.org
Email Address
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Members

Alexa Borkowski

Administrative Assistant

Daniel Ball, Research Fellow
Daniel Ball

Research Fellow

Kathleen Bishop

Research Technician

Timothy Bishop

Research Scholar

Michael Geeson

Research Fellow

Lauren Hollmer

Graduate Student

Hsin-Che Huang

Graduate Student

Zhencheng Lai

Research Scholar

Donyell Logan

MSK Bridge Program Scholar

Lourdes Pajuelo

Graduate Student

Lydia Tsamouri

Graduate Student

Ashley Tucewicz

Graduate Student

Anqi Zhou

Graduate Student

Lab Alumni
Abir Bhattacharjee
Abir Bhattacharjee

Research Fellow

Qifeng Chen
Qifeng Chen

Research Fellow

Ashley  Chui
Ashley Chui

Graduate Student

Kuo Gai, Research Technician
Kuo Gai

Research Technician

Andrew Griswold
Andrew Griswold

Graduate Student

Jeff Chieh Hsiao
Jeff Chieh Hsiao

Graduate Student

Darren Johnson
Darren Johnson

Graduate Student

Marian Okondo
Marian Okondo

Research Technician

Elizabeth Orth

Graduate Student

Sahana Rao
Sahana Rao

Graduate Student

Cornelius Taabazuing
Cornelius Taabazuing

Research Fellow

Alvin Wang
Alvin Wang

Research Technician

Qinghui Wang
Qinghui Wang

Research Fellow

Lab Affiliations

Achievements

  • David P. Hajjar Excellence in Teaching and Mentoring Award, Weill Cornell Graduate School (2023)
  • Louise and Allston Boyer Young Investigator Award for Distinguished Achievement in Basic Research (2021)
  • Sloan Research Fellow in Chemistry (2018)
  • Pew-Stewart Scholar for Cancer Research (2017)
  • Pershing Square Sohn Prize for Young Innovators in Cancer Research (2018)
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  • Josie Robertson Investigator (2015-2020)
  • Stand Up to Cancer 2017 Innovative Research Grant Recipient (2017)
  • California Breast Cancer Research Program Fellowship (2011)
  • National Science Foundation Predoctoral Fellowship (2006)

Open Positions

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Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Daniel Bachovchin discloses the following relationships and financial interests:

  • AbbVie
    Professional Services and Activities

The information published here is a complement to other publicly reported data and is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.


This page and data include information for a specific MSK annual disclosure period (January 1, 2023 through disclosure submission in spring 2024). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at ecoi@mskcc.org.


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