Chemical Biology Program

The Daniel Bachovchin Lab

Research

Daniel Bachovchin, PhD

Geoffrey Beene Junior Faculty Chair

The Bachovchin lab uses chemical and cell biology approaches to study important questions in innate immunity. We are particularly interested in characterizing the molecular mechanisms controlling the formation of inflammasomes, key components of the innate immune system that sense intracellular danger signals and trigger pyroptotic cell death.

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Go inside the lab of Daniel Bachovchin from SKI’s Chemical Biology Program.

Video Details

Featured News

MSK chemical biologist Daniel Bachovchin in his laboratory

At Work: Chemical Biologist Daniel Bachovchin

Meet chemical biologist Daniel Bachovchin.

Science Byte

Scientists Discover Keys to Immune Response against Anthrax

Researchers clarify how the immune system activates an inflammatory defense against pathogens.

In the Lab

Image of fireball-type explosion on black background.

Researchers Gain Insight into How a Drug Fires Up an Immune Response to Cancer

Scientists have learned that a drug activates a form of highly inflammatory programmed cell death called pyroptosis — a discovery that sheds light on immune function.

Publications Highlights

Chui, A.J*; Okondo, M.C.*; Rao, S.D.*; Gai, K.; Griswold, A.R.; Johnson, D.C.; Ball, D.P.; Taabazuing, C.Y.; Orth, E.L.; Vittimberga, B.A.; Bachovchin, D.A. # “N-terminal degradation activates the Nlrp1b inflammasome.” Science. 2019, 365, 82-85.

Rao, S.D.*; Chen, Q.*; Wang, Q.*; Orth-He, E.L.*; Saoi, M.; Griswold, A.R.; Bhattacharjee, A.; Ball, D.P.; Huang, H.-C.; Chui, A.J.; Covelli, D.J.; You, S.; Cross, J.R.; Bachovchin, D.A. # “M24B aminopeptidase inhibitors selectively activate the CARD8 inflammasome.” Nat Chem Biol. 2022, 18, 565-574.

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People

Daniel Bachovchin, PhD

Geoffrey Beene Junior Faculty Chair

Chemical biologist Daniel Bachovchin designs selective inhibitors to study enzymes and pathways in cancer and immune system signaling.
PhD, The Scripps Research Institute
AB, Harvard College

bachovcd@mskcc.org: Email Address
Download CV: PDF File

Members

Alexa Borkowski

Administrative Assistant

Daniel Ball

Research Fellow

Timothy Bishop

Research Scholar

Maximus Chen

Graduate Student

Lauren Hollmer

Graduate Student

Zhencheng Lai

Research Scholar

Lourdes Pajuelo

Graduate Student

Andrea Tellez

Graduate Student

Marianna Teplova

Senior Research Scientist

Lydia Tsamouri

Graduate Student

Anqi Zhou

Graduate Student

Abir Bhattacharjee

Research Fellow

Kathleen Bishop

Research Technician

Qifeng Chen

Research Fellow

Ashley Chui

Graduate Student

Kuo Gai

Research Technician

Michael Geeson

Research Fellow

Andrew Griswold

Graduate Student

Jeff Chieh Hsiao

Graduate Student

Hsin-Che Huang

Graduate Student

Darren Johnson

Graduate Student

Donyell Logan

MSK Bridge Program Scholar

Marian Okondo

Research Technician

Elizabeth Orth

Graduate Student

Sahana Rao

Graduate Student

Cornelius Taabazuing

Research Fellow

Ashley Tucewicz

Graduate Student

Alvin Wang

Research Technician

Qinghui Wang

Research Fellow

Achievements

David P. Hajjar Excellence in Teaching and Mentoring Award, Weill Cornell Graduate School (2023)
Louise and Allston Boyer Young Investigator Award for Distinguished Achievement in Basic Research (2021)
Sloan Research Fellow in Chemistry (2018)
Pew-Stewart Scholar for Cancer Research (2017)
Pershing Square Sohn Prize for Young Innovators in Cancer Research (2018)

Josie Robertson Investigator (2015-2020)
Stand Up to Cancer 2017 Innovative Research Grant Recipient (2017)
California Breast Cancer Research Program Fellowship (2011)
National Science Foundation Predoctoral Fellowship (2006)

Open Positions

To learn more about available postdoctoral opportunities, please visit our Career Center

To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs

Graduate Students

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Postdoctoral Fellows

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Get in Touch

bachovcd@mskcc.org

Lab Head Email

Disclosures

Members of the MSK Community often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community. These activities outside of MSK further our mission, provide productive collaborations, and promote the practical application of scientific discoveries.

MSK requires doctors, faculty members, and leaders to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public. Not all disclosed interests and relationships present conflicts of interest. MSK reviews all disclosed interests and relationships to assess whether a conflict of interest exists and whether formal COI management is needed.

Daniel Bachovchin discloses the following relationships and financial interests:

No disclosures meeting criteria for time period

The information published here is a complement to other publicly reported data and is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2024 through disclosure submission in spring 2025). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at ecoi@mskcc.org.

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