Chemical Biology Program
The Daniel Bachovchin Lab
Research
The Bachovchin lab uses chemical and cell biology approaches to study important questions in innate immunity. We are particularly interested in characterizing the molecular mechanisms controlling the formation of inflammasomes, key components of the innate immune system that sense intracellular danger signals and trigger pyroptotic cell death.
Featured News
Publications Highlights
Chui, A.J*; Okondo, M.C.*; Rao, S.D.*; Gai, K.; Griswold, A.R.; Johnson, D.C.; Ball, D.P.; Taabazuing, C.Y.; Orth, E.L.; Vittimberga, B.A.; Bachovchin, D.A. # “N-terminal degradation activates the Nlrp1b inflammasome.” Science. 2019, 365, 82-85.
Rao, S.D.*; Chen, Q.*; Wang, Q.*; Orth-He, E.L.*; Saoi, M.; Griswold, A.R.; Bhattacharjee, A.; Ball, D.P.; Huang, H.-C.; Chui, A.J.; Covelli, D.J.; You, S.; Cross, J.R.; Bachovchin, D.A. # “M24B aminopeptidase inhibitors selectively activate the CARD8 inflammasome.” Nat Chem Biol. 2022, 18, 565-574.
People
Daniel Bachovchin, PhD
Geoffrey Beene Junior Faculty Chair
- Chemical biologist Daniel Bachovchin designs selective inhibitors to study enzymes and pathways in cancer and immune system signaling.
- PhD, The Scripps Research Institute
- AB, Harvard College
- bachovcd@mskcc.org
- Email Address
- Download CV
- PDF File
Members
Lab Alumni
Lab Affiliations
Achievements
- David P. Hajjar Excellence in Teaching and Mentoring Award, Weill Cornell Graduate School (2023)
- Louise and Allston Boyer Young Investigator Award for Distinguished Achievement in Basic Research (2021)
- Sloan Research Fellow in Chemistry (2018)
- Pew-Stewart Scholar for Cancer Research (2017)
- Pershing Square Sohn Prize for Young Innovators in Cancer Research (2018)
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- Josie Robertson Investigator (2015-2020)
- Stand Up to Cancer 2017 Innovative Research Grant Recipient (2017)
- California Breast Cancer Research Program Fellowship (2011)
- National Science Foundation Predoctoral Fellowship (2006)
Open Positions
To learn more about available postdoctoral opportunities, please visit our Career Center
To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs
Get in Touch
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Lab Head Email
Disclosures
Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.
Daniel Bachovchin discloses the following relationships and financial interests:
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AbbVie
Professional Services and Activities
The information published here is a complement to other publicly reported data and is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.
This page and data include information for a specific MSK annual disclosure period (January 1, 2023 through disclosure submission in spring 2024). This data reflects interests that may or may not still exist. This data is updated annually.
Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at ecoi@mskcc.org.