Cell Biology Program
The Marilyn Resh Lab
Research
Marilyn Resh, PhD
Member
The goal of my laboratory’s research is to understand how fatty acylation influences the structure and function of membrane-bound and secreted signaling proteins. Our focus is on the Src family tyrosine protein kinases, Hedgehog and Wnt proteins.
Research Projects
People
Marilyn Resh, PhD
Member
- Cell biologist Marilyn Resh investigates the regulation of protein function by fatty acylation, and the development of Hedgehog palmitoylation inhibitors to block pancreatic and lung cancer.
- PhD, Harvard University
- AB, Princeton University
- m-resh@ski.mskcc.org
- Email Address
- 212-639-2514
- Office Phone
Members
Sr. Administrative Assistant
Graduate Student
Postdoctoral Fellow
Research Fellow
Associate Manager, Research Program Management, Regeneron Pharmaceuticals
Postdoctoral Fellow
Research Technician
Member
Student Research Assistant
Graduate Student
Principal Scientist at EMD Sero Inc., Cambridge, MA
Achievements
- Excellence in Teaching and Mentoring Award, Weill Cornell Graduate School (2009)
- Established Scientist, American Heart Association (1994-1999)
- Pew Scholar in the Biomedical Sciences, Pew Charitable Trusts (1987-1991)
- Discovery of the ""two-signal hypothesis"" for binding of myristoylated proteins to membranes
- Discovery of a myristoyl switch mechanism for membrane binding of HIV-1 Gag
- First to establish Hedgehog acyltransferase as a bona fide palmitoyl acyltransferase for Hedgehog proteins
- Discovery of the first-in-class hedgehog palmitoylation inhibitor