Cancer Biology & Genetics Program
The Scott Lowe Lab
Research
About the Scott Lowe Lab
Cancer biologist Scott Lowe uses genetically engineered mouse models to study how the genetic alterations in cancer cells contribute to tumorigenesis, alter treatment response, and create molecular vulnerabilities that may be targeted therapeutically.
Cancer arises through an evolutionary process whereby normal cells acquire mutations that erode growth controls. Still, cancer is not an inevitable consequence of mutation, but is kept in check by intrinsic tumor-suppressor programs activated in damaged cells. We study such programs to reveal, and ultimately exploit, the strategies nature uses to combat cancer.
Our early studies focused on cell-intrinsic programs that prevent tumorigenesis (e.g., apoptosis, senescence), and have broadened to cell-extrinsic mechanisms (e.g., immune surveillance). New areas of interest include how tumor-suppressive programs are blunted by environmental factors known to increase cancer incidence (e.g., obesity, aging) and how excessive activation of tumor-suppressive programs (e.g., senescence) can harm function of normal tissue. To gain a mechanistic understanding of these phenomena, we apply mouse models in which cancer arises in an intact tissue ecosystem, which is a long-standing strength of our program. Our affiliation with Memorial Sloan Kettering Cancer Center enables us to probe human systems as well.
Another major goal is to harness our knowledge of tumor suppression therapeutically. We and others have shown that reengaging tumor-suppressive programs in established cancer cells can coordinate tumor regression through both cell-intrinsic and cell-extrinsic components (1-5), so these programs represent attractive strategies for tumor control. With Michel Sadelain, we have also developed a cell therapy approach to remove excessive senescent cells from tissues (6); this therapy may have beneficial effects on cancer and non-cancer pathologies. Advancing these concepts are major goals of our current research.
Research Projects
Featured News
People
Scott W. Lowe, PhD
Chair, Cancer Biology & Genetics Program, SKI; Chair, Geoffrey Beene Cancer Research Center; Investigator, Howard Hughes Medical Institute
- PhD, Massachusetts Institute of Technology
- lowes@mskcc.org
- Email Address
- 646-888-3342
- Office Phone
- Download CV
- PDF File
Members
Postdoctoral Researcher
Administrative Coordinator
Graduate Student
Postdoctoral Researcher
Postdoctoral Researcher
Graduate Student
Research Technician
Lead Program Manager
Graduate Student
Postdoctoral Researcher
Computational Biologist
Graduate Student
Senior Research Technician
Postdoctoral Researcher
Postdoctoral Researcher
Postdoctoral Researcher
Postdoctoral Researcher
Assistant to Chair
Mouse Colony Manager
Research Technician
Senior Research Technician
Lab Manager
Postdoctoral Researcher
Postdoctoral Researcher
Lab Alumni
Instructor in Medicine
Junior Group Leader, Cancer Science, IRB Barcelona, Spain
Group Leader - Cancer Genome Engineering Lab Vall D´Hebron Institute of Oncology (VHIO)
Physician, University Hospital RWTH Aachen, Germany
CSHL Independent Fellow at Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
Group Leader, German Cancer Research Center (DKFZ), Heidelberg, Germany
Principal Scientist, CTI, Pfizer Research, New York
Data Scientist, Agios Pharmaceuticals, Inc., Cambridge, MA
Postdoctoral Fellow at Rockefeller University, New York, NY
Professor, Sichuan University, Sichuan, China
Assistant Professor, Weill Cornell Medical College, New York, NY
Director, Medical & Scientific Strategy, BluPrint Oncology, London
Senior Scientist, Oncology Biomarker Development, Genentech, San Francisco, CA
Associate Director, Liver Research, Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY
Postdoctoral Fellow, Harvard University, Cambridge, MA
Co-Founder & CEO, Algen Biotechnologies, San Francisco, CA
Postdoctoral Associate, Weill Cornell Medicine, New York, NY
Senior Research Scientist, Philipps University of Marburg, Institute of Pharmacology, Germany
Group Leader, University of Tübingen, Germany
Professor, Sichuan University, Sichuan, China
Senior Research Analyst, Biotechnology and Pharmaceuticals, Chardan Capital Markets LLC, New York, NY
Group Leader, Altos Labs, San Francisco, CA
Analyst, Nexttech, Boston, MA
Assistant Professor of Biology, Massachusetts Institute of Technology, Cambridge, MA
Senior Research Associate, Intelligencia, New York, NY
Associate Professor, Mount Sinai School of Medicine, New York, NY
Senior Principal Scientist, Novartis, Basel, Switzerland
Assistant Director, DNALC, Cold Spring Harbor Laboratory, New York
Senior Scientist, Pfizer, San Francisco, CA
Group Leader and Medical Fellow, University Medical Center Freiburg, Germany
Assistant Professor, Department of Pharmacology, University of North Carolina, Chapel Hill, NC
Investments, Roivant Sciences, New York, NY
Clinical Fellow, Pediatrics, Boston Children's Hospital, Boston, MA
Assistant Professor, Molecular, Cell & Cancer Biology, University of Massachusetts Medical School, Worcester, MA
Physician, Hannover Medical School, Germany
Physician, Hannover Medical School, Germany
Chair, Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, TN
Senior Scientist, Functional Genomics, Target Sciences, Pfizer, New York, NY
Group Leader, German Cancer Research Center (DKFZ), Heidelberg, Germany
Strategic Partnering Associate, Roche, Basel, Switzerland
Pathology Resident, The Mount Sinai Hospital, New York, NY
Research Specialist, Weill Cornell Medicine, New York, NY
Research Technician
Research Technician
Research Technician
Research Technician
Research Technician
Research Technician
Research Technician
Research Technician
Research Technician
Research Technician
Research Technician
Research Technician
Research Technician
Research Technician
Laboratory Manager
