Chemical Biology Program

The Yueming Li Lab

Research

Yueming Li, PhD

Research Interests

Basic & Translational research in Cancer and Alzheimer’s disease:
From disease mechanism to therapeutic development.

Research Areas

Target Identification & Drug Discovery
Chemical Biology & Medicinal Chemistry
Biochemistry & Enzymology
Biophysics & Structural Biology
Animal models & Behavior
Neurobiology & Neuroinflammation
Autophagy, Protein Aggregation & Clearance

Learn more

Research Projects

Research Projects

Featured News

At Work: Biochemist Yueming Li

Yueming Li aims to develop new agents that inhibit particular intramembrane proteases associated with cancer.

Article

An illustration of a beta-amyloid plaque among the neurons in a brain.

MSK Study Links Inflammation to Alzheimer’s Disease Development

An enzyme that contributes to plaque formation in the brain also serves as a first line of defense against bacteria and viruses, suggesting a link between the two.

Nanotechnology May Aid Diagnosis

Biochemist Yueming Li commented on new technology that is three million times more sensitive at detecting Alzheimer's disease and certain cancers....

Publications Highlights

Nie P, Kalidindi T, Nagle VL, et al. Imaging of Cancer γ-Secretase Activity Using an Inhibitor-Based PET Probe. Clin Cancer Res. 2021;27(22):6145-6155. doi:10.1158/1078-0432.CCR-21-0940

Hur, J.-Y., Frost, G. R., Wu, X., Crump, C., Pan, S. J., Wong, E., … Li, Y.-M. (2020). The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer’s disease. Nature. doi:10.1038/s41586-020-2681-2

Mekala, S., Nelson, G., & Li, Y.-M. Recent developments of small molecule γ-secretase modulators for Alzheimer’s disease. RSC Medicinal Chemistry, 11(9), 1003-1022. doi:10.1039/D0MD00196A (2020)

View All Publications

People

Yueming Li, PhD

Dr. Yueming Li studies disease mechanism of Cancer and Alzheimer’s, with the goal of developing novel therapeutics for clinical use.
PhD, University of California Berkeley

liy2@mskcc.org: Email Address
646-888-2194 or 2193: Office Phone

Members

Yueming Li

Lab Head

Pascale M. Presendor

Administrative Assistant

Ji Yeun Hur

Senior Research Scientist

Eitan Wong

Postdoctoral Fellow

Joanna Zhai

Postdoctoral Fellow

Lauren A. Jonas

Graduate Student

Joanna Luo

Graduate Student

Pengju Nie

Graduate Student

Jessica Falci

Graduate Student

Tanya Jain

Graduate Student

Zoe Kehs

Graduate student

Chenge Liu

Shekar Mekala

Senior Research Scientist

Grady Nelson

Postdoctoral Fellow

Cyrus Nikain

Graduate student

Antara Sinha

Postdoctoral Fellow

Daniel W. Worroll III

Graduate Student

Alissa Brandes

Graduate Student

Courtney Carroll

Graduate Student

Xianzhong Wu

Laboratory Manager

Danica Chiu

Graduate Student

Marilia Barros

Postdoctoral Fellow

Natalya Gertsik

Graduate Student

Qi Liu

Research Fellow

Jessica Pan

Postdoctoral Fellow

David Schachter

Graduate Student

Georgia Frost

Postdoctoral Fellow

Chelsea Paresi

Graduate Student

Thomas Li

Graduate Student

George Liao

Graduate Student

Courtney Alexander

Graduate Student

Suita Castro

Research Technician

Deming Chau

Postdoctoral Fellow

Jennifer Chien

Postdoctoral Fellow

Christina J. Crump

Graduate Student

Kelly (Yunke) Guo

Graduate Student

Shan Li

Visiting Student

Jian Luan

Visiting Scholar

Manish Malviya

Senior Research Scientist

Wenbo Pei

Abhishek Vartak

Postdoctoral Fellow

Xiaojun Lei

Graduate Student

Yuan Tian

Graduate Student

Lisa Placanica

Graduate Student

Kwangwook Ahn

Research Fellow

C. Chad Shelton

Graduate Student

Lane M. Gilchrist

Sabbatical Professor

Haige Lu

Research Fellow

Bhramdeo Bassit

Research Technician

Lei Zhu

Research Fellow

Leonid Tarassishin

Research Fellow

Jiong Chun

Research Fellow

Ingrid Ye Yin

Research Fellow

Open Positions

To learn more about available postdoctoral opportunities, please visit our Career Center

To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs

Career Opportunities

Apply now

Get in Touch

liy2@mskcc.org

Lab Head Email
646-888-2194 or 2193

Office Phone
646-422-0640

Office Fax
646-888-2204 or 2531

Lab Phone

Disclosures

Members of the MSK Community often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community. These activities outside of MSK further our mission, provide productive collaborations, and promote the practical application of scientific discoveries.

MSK requires doctors, faculty members, and leaders to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public. Not all disclosed interests and relationships present conflicts of interest. MSK reviews all disclosed interests and relationships to assess whether a conflict of interest exists and whether formal COI management is needed.

Yueming Li discloses the following relationships and financial interests:

Biogen MA Inc.
Professional Services and Activities
BrightFocus Foundation
Professional Services and Activities

Cure Alzheimer's Fund
Professional Services and Activities
Jiangsu Continental Medical Development Co
Intellectual Property Rights

The information published here is a complement to other publicly reported data and is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2024 through disclosure submission in spring 2025). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at ecoi@mskcc.org.

View all disclosures