The Andrea Schietinger Lab
Research
The goal of our laboratory is to understand when, why, and how immune cells become unresponsive to tumors or self-destructive in autoimmune diseases. We develop genetic cancer mouse models that mimic cancer development in patients, investigate T cell responses over the course of tumor development, and define the molecular mechanisms that are responsible for the failure to control and eliminate tumors. In addition, we utilize clinically relevant mouse models of autoimmunity, such as Type 1 Diabetes, to understand how autoimmune responses are initiated and sustained. Our ongoing and future research programs aim to develop a deep mechanistic understanding of the spatiotemporal, molecular, and epigenetic factors that determine T cell fate decisions and functional/dysfunctional states in cancer and autoimmunity, and test innovative conceptual frameworks and T cell reprogramming approaches for the treatment of T cell-mediated diseases. Detailed information about our research is available at www.schietingerlab.com.
Featured News
Publications Highlights
Gearty SV, Dündar F, Zumbo P, Espinosa-Carrasco G, Shakiba M, Sanchez-Rivera F, Socci ND, Trivedi D, Lowe SW, Lauer P, Mohibullah N, DiLorenzo TP, Viale A, Betel D, Schietinger A. A stem-like autoimmune CD8 T cell population drives type 1 diabetes. Nature 2022 Feb;602(7895):156-161.
Shakiba M, Zumbo P, Dündar F, Espinosa-Carrasco G, Camara S, Sanchez-Rivera FG, Lowe SW, Koche RP, Reuter VP, Socci ND, Whitlock B, Tamzalit F, Huse M, Betel D, Philip M, Schietinger A. TCR signal strength defines distinct mechanisms of T cell dysfunction and cancer evasion. Journal of Experimental Medicine 2022 Feb 7;219(2):e20201966.
Philip M and Schietinger A. CD8 T cell differentiation and dysfunction in cancer. Nature Reviews Immunology. 2022 Apr;22(4):209-223.
People
Andrea Schietinger, PhD
Catherine and Frederick R. Adler Chair for Junior Faculty
- Cancer Immunologist Andrea Schietinger investigates immune responses to cancer, molecular mechanisms underlying tumor-induced T cell dysfunction, and new approaches for cancer immunotherapy.
- PharmD, University of Hamburg, PhD, University of Chicago, Chicago, IL and University of Munich, Germany
- Postdoctoral Training: Fred Hutchinson Cancer Research Center and University of Washington, Seattle
- schietia@mskcc.org
- Email Address
- 646-888-3754
- Office Phone
Members
- BS, The City College of New York
- Cancer Biology
Achievements
- AACR-Irving Weinstein Foundation Distinguished Lectureship Award (2023)
- American Association of Immunologists - AAI BD Biosciences Investigator Award (2022)
- AACR-Bristol Myers Squibb Midcareer Female Investigator Award (2021)
- Catherine and Frederick R. Adler Chair for Junior Faculty (2021)
- Louise and Allston Boyer Young Investigator Award for Basic Research (2020)
- Pershing Square Sohn Award (2020)
- Josie Robertson Investigator (2014-2019)
- Cancer Research Institute Lloyd Old STAR Award (2019)
- NIH Director’s Innovator Award (2017)
- NIH/NCI K99/R00 Award (2015)
- V Foundation for Cancer Research Award (2015)
- William and Ella Owens Medical Research Foundation Award (2016)
- Cancer Research Institute Irvington Fellowship (2012)
Open Positions
To learn more about available postdoctoral opportunities, please visit our Career Center
To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs
Tumor Immunology
Get in Touch
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Lab Head Email
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Office Phone
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Office Fax
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Assistant: Nadine Hernandez
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Lab Phone
Disclosures
Members of the MSK Community often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community. These activities outside of MSK further our mission, provide productive collaborations, and promote the practical application of scientific discoveries.
MSK requires doctors, faculty members, and leaders to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public. Not all disclosed interests and relationships present conflicts of interest. MSK reviews all disclosed interests and relationships to assess whether a conflict of interest exists and whether formal COI management is needed.
Andrea Schietinger discloses the following relationships and financial interests:
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American Association for Cancer Research
Professional Services and Activities (Uncompensated) -
Boehringer Ingelheim Fonds
Professional Services and Activities (Uncompensated) -
CICON International Cancer Immunotherapy Conference
Professional Services and Activities (Uncompensated) -
Cold Spring Harbor Laboratory
Professional Services and Activities (Uncompensated) -
European Society for Medical Oncology (ESMO)
Professional Services and Activities (Uncompensated) -
Federation of American Societies for Experimental Biology (FASEB)
Professional Services and Activities (Uncompensated) -
Immunology of Diabetes Society (IDS)
Professional Services and Activities (Uncompensated) -
Immunotherapy of Cancer Conference (ITOC)
Professional Services and Activities (Uncompensated) -
Karolinska Institute
Professional Services and Activities (Uncompensated) -
McGill University
Professional Services and Activities (Uncompensated)
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MD Anderson
Professional Services and Activities (Uncompensated) -
Midwinter Conference of Immunologists
Professional Services and Activities (Uncompensated) -
National Institutes of Health (NIH)
Professional Services and Activities; Professional Services and Activities (Uncompensated) -
Salk Institute for Biological Studies
Professional Services and Activities (Uncompensated) -
Springer Nature Limited
Professional Services and Activities (Uncompensated) -
University of Freiburg
Professional Services and Activities (Uncompensated) -
University of Lausanne
Professional Services and Activities (Uncompensated) -
University of Miami
Professional Services and Activities (Uncompensated) -
University of Utah
Professional Services and Activities -
Yale University
Professional Services and Activities (Uncompensated)
The information published here is a complement to other publicly reported data and is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.
This page and data include information for a specific MSK annual disclosure period (January 1, 2024 through disclosure submission in spring 2025). This data reflects interests that may or may not still exist. This data is updated annually.
Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at ecoi@mskcc.org.