Chemical Biology Program
The Arvin Dar Lab
Research
The Dar laboratory explores cancer mechanisms and new approaches in chemical biology. Our research integrates genetics, biochemistry, structure, and small molecule discovery. Our primary goal is to develop tools that enable us to modulate cell signaling networks, allowing for in-depth mechanistic exploration of disease and potential therapeutic applications.
In our previous work, we successfully designed chemical switches and conformational modulators that selectively bind to specific targets of interest. By manipulating the conformational equilibrium, we can effectively influence the formation of specific states or complexes. Another area of research has been on molecular glues that operate at the interface of biomolecular complexes to regulate the assembly, lifetime, and fate of signal transduction events.
Overall, we are focused on the development of chemical tools and probes to target cancers driven by dysregulated enzymes, receptors, cellular communication pathways, and the tumor microenvironment.
Research Projects
People
Arvin Dar, PhD
Benno C. Schmidt Chair of Cancer Research
- Arvin Dar’s lab develops chemical tools and probes to explore disease mechanisms and the structural biology of cancer targets.
- PhD, University of Toronto, Toronto, Ontario
- dara1@mskcc.org
- Email Address
- 212-639-8825
- Office Phone
Members
Research Scholar
Administrative Assistant
TPCB Student
Research Scholar
Graduate Student
Research Scholar
Senior Research Scientist
Research Scholar
Research Assistant
Research Scholar
Senior Research Scientist
Lab Alumni
Lab Affiliations
Achievements
- Mark Foundation for Cancer Research ASPIRE Award
- Friedman Brain Institute Scholar
- Pershing Square Sohn Prize for Young Investigators (PSSCRA)
- Pew-Stewart Scholars for Cancer Research (Pew Foundation)
- Damon Runyon-Rachleff Innovation Award
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- NIH Director’s New Innovator Award