Structural Biology Program
The Christopher Lima Lab
Research
Christopher D. Lima, PhD
Member and Chair, Structural Biology Program, SKI; Investigator, Howard Hughes Medical Institute; Alfred P. Sloan Chair
We are a research laboratory that studies fundamental structural, biochemical, and functional attributes for macromolecules involved in post-translational protein modification by ubiquitin and ubiquitin-like proteins such as SUMO, and pathways that contribute to co- and post-transcriptional RNA maturation, processing and decay. We pursue biochemical approaches to reconstitute key intermediates or complexes in these pathways and combine them with single particle cryo-EM and x-ray crystallography in conjunction with genetics and biochemistry to elucidate structure/activity relationships.
Research Projects
Featured News
With Cryo-EM, SKI Scientists Determine Structure of Key Factor in RNA Quality Control
Called NEXT, the factor plays an important role in handing over RNA to the exosome for destruction.
In the Clinic
MSK Antibody Test Will Aid Understanding of Immune Response to COVID-19 Virus
An antibody test developed at MSK could shed light on the immune response to the COVID-19 virus.
Two Sloan Kettering Institute Scientists Elected to Esteemed National Academy of Sciences
Membership is a widely accepted mark of excellence in science and considered one of the highest honors a scientist can receive.
People
Christopher D. Lima, PhD
Member and Chair, Structural Biology Program, SKI; Investigator, Howard Hughes Medical Institute; Alfred P. Sloan Chair
- The Lima laboratory studies mechanisms underlying RNA processing as well as post-translational protein modification by ubiquitin-like proteins.
- PhD, Northwestern University
- limac@mskcc.org
- Email Address
- 212-639-8205
- Office Phone
Members
Research Fellow
Graduate Student
Research Fellow
Research Fellow
Assistant to the Chair
Research Fellow
Graduate Student
Graduate Student
Research Fellow
Research Fellow
Graduate Student
Member; Chair, Structural Biology Program, SKI
Senior Research Technician
Visiting Research Fellow
Research Fellow
Senior Research Scientist
Research Fellow
Graduate Student
Graduate Student (BCMB)
Research Fellow
Postdoctoral Fellow, Memorial Sloan Kettering Cancer Center
Research Fellow
Senior Research Scientist
Research Technician
Graduate Student
Research Fellow
Graduate Student
Research Technician
Graduate Student and Research Fellow
Research Technician
Research Fellow
Research Technician
Graduate Student
Research Fellow
Research Fellow
Research Technician
Research Fellow
Research Fellow
Research Technician
Research Fellow
Research Fellow
Research Fellow
Research Technician
Graduate Student
Senior Research Scientist
Research Fellow
Graduate Student
Research Fellow
Graduate Student
Research Fellow
Research Fellow
Graduate Student
Graduate Student
Graduate Student
Achievements
- Member, National Academy of Sciences (2020)
- Fellow of the American Academy of Arts and Sciences (2017)
- Investigator, Howard Hughes Medical Institute (2013)
- Louise and Allston Boyer Young Investigator in Basic Research, Memorial Sloan Kettering Cancer Center (2006)
- Scholar, Rita Allen Foundation (2003-2006)
- Mayor's Award for Excellence in Science and Technology, NYC Department of Cultural Affairs and New York Academy of Sciences (2003)
- Young Investigator Award, Arnold and Mabel Beckman Foundation (1999-2002)
Related topics:
