Immunology Program
The Gretchen Diehl Lab
Research
The intestinal immune system faces a number of unique challenges due to continuous exposure to rapidly changing exogenous factors including diet and intestinal microbes. Proper calibration of responses is needed to clear invading pathogens as well as repair damage. Over enthusiastic responses within the intestine impair barrier repair, amplifying damage and potentially lead to systemic infection or chronic inflammatory disease including inflammatory bowel disease (IBD). We find that the intestinal microbiota and dietary factors can promote or inhibit proper immune regulation. As such, we seek to define molecular and cellular pathways regulated by the microbiota, dietary, and tissue factors that are required to maintain homeostasis within the intestine. In defining upstream signals, we are working to understand microbial pathways and how they modulate tissue immunity. In parallel, we seek to delineate how these networks are disrupted in inflammatory conditions.
Featured News
Publications Highlights
Hill AA, Kim M, Zegarra-Ruiz DF, Chang LC, Norwood K, Assié A, Wu WH, Renfroe MC, Song HW, Major AM, Samuel BS, Hyser JM, Longman RS, Diehl GE*. Acute high-fat diet impairs macrophage-supported intestinal damage resolution. JCI Insight. 2023 Feb 8 ;8(3):e164489.
Zegarra Ruiz DF, Kim DV, Norwood K, Saldana-Morales FB, Kim M, Ng C, Callaghan R, Uddin M, Chang LC, Longman RS, Diehl GE*. Microbiota manipulation to increase macrophage IL-10 improves colitis and limits colitis-associated colorectal cancer. Gut Microbes. 2022 Jan-Dec ;14(1):2119054.
People
Gretchen Diehl, PhD
Catherine and Frederick R. Adler Chair for Junior Faculty
- The Diehl lab studies how the microbiota and other exogenous factors regulate development and function of the intestinal immune system.
- PhD, University of California, Berkeley
- diehlg1@mskcc.org
- Email Address
Members
- 646-888-2120
- Lab Phone
Lab Alumni
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Disclosures
Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.
Gretchen Diehl discloses the following relationships and financial interests:
No disclosures meeting criteria for time period
The information published here is a complement to other publicly reported data and is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.
This page and data include information for a specific MSK annual disclosure period (January 1, 2023 through disclosure submission in spring 2024). This data reflects interests that may or may not still exist. This data is updated annually.
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