Immunology Program
The Gretchen Diehl Lab
Research
The intestinal immune system faces a number of unique challenges due to continuous exposure to rapidly changing exogenous factors including diet and intestinal microbes. Proper calibration of responses is needed to clear invading pathogens as well as repair damage. Over enthusiastic responses within the intestine impair barrier repair, amplifying damage and potentially lead to systemic infection or chronic inflammatory disease including inflammatory bowel disease (IBD). We find that the intestinal microbiota and dietary factors can promote or inhibit proper immune regulation. As such, we seek to define molecular and cellular pathways regulated by the microbiota, dietary, and tissue factors that are required to maintain homeostasis within the intestine. In defining upstream signals, we are working to understand microbial pathways and how they modulate tissue immunity. In parallel, we seek to delineate how these networks are disrupted in inflammatory conditions.
Featured News
People
Gretchen Diehl, PhD
Catherine and Frederick R. Adler Chair for Junior Faculty
- The Diehl lab studies how the microbiota and other exogenous factors regulate development and function of the intestinal immune system.
- PhD, University of California, Berkeley
- diehlg1@mskcc.org
- Email Address
Members
Member, Immunology Program, Catherine and Frederick R. Adler Chair for Junior Faculty
Research Scholar
Graduate Student
Research Scholar
Graduate Student
Graduate Student
Graduate Student
Graduate Student
Research Technician
Administrative Assistant
Research Scholar
Research Scholar
Research Scholar
Research Technician
Research Scholar
Lab Alumni
Senior Research Scientist
Postdoctoral Associate
Graduate Student
Research Fellow
MSK Bridge Program Scholar
Administrative Assistant II
