A Phase 2 Study of Tebentafusp in People With Advanced Clear Cell Sarcoma

Full Title

Purpose

Researchers want to see how well tebentafusp works in people with clear cell sarcoma that has spread. This cancer grows deeply into soft tissues of the arms and legs. The people in this study have clear cell sarcoma that is inoperable (cannot be surgically removed) or has spread.

Tebentafusp is a type of drug called a bispecific protein, which means it binds to two different proteins. It binds to one protein on cancer cells and another on immune cells called T cells. Tebentafusp may strengthen your immune system’s ability to fight cancer cells by activating your own cells to destroy your tumor. It is given intravenously (by vein).

Who Can Join

To join this study, there are a few conditions. You must:

• Have inoperable or metastatic clear cell sarcoma.
• Be positive for HLA-A*02:01. HLA is an antigen on the surface of your cells. 
• Be able to walk and do routine activities for more than half the time you are awake.
• Be age 18 or older.

Contact

For more information or to see if you can join this study, please call Dr. Sandra P. D’Angelo’s office at 646-888-4159.