Antitumor Assessment

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Overview

Elisa de Stanchina
Director

The Antitumor Assessment (ATA) Core provides support for early discovery and in vivo testing of antitumor detection and therapeutic agents. The Core provides resources, professional and technical expertise, and advisory services related to the evaluation of agents with potential diagnostic or therapeutic activity. The ATA Core works closely with investigators to establish preclinical models, including Patient-Derived Xenograft (PDX) and Patient-Derived Organoid (PDO) models, for the design and execution of pharmacokinetic (PK), toxicity, and in vivo efficacy studies. The Core also assists investigators in determining the best formulation, administration route, and treatment schedule for each new compound, either alone or in combination with other agents. As such, the Core provides a major vehicle to facilitate preclinical studies, including Good Laboratory Practice (GLP)-compliant safety toxicology studies in support of Investigational New Drug (IND) applications, and is a major contributor to the translational mission of the Center. The Core helps investigators design, plan, and execute in vivo experiments, prepare animal protocols and grant applications involving animal studies, and analyze and summarize data for publication and for IND reporting. Importantly, the ATA Core acts as a central coordinator for studies involving support from several Shared Resources and centralized services at MSK (including Animal Imaging, Center for Comparative Medicine & Pathology, Integrated Genomics Operation, Organic Synthesis, Radiochemistry and Molecular Imaging Probes, and Molecular Cytology Cores, as well as MSK’s Tissue Procurement Service) so that studies are conducted properly and in a time- and cost-efficient manner.

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Featured News

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Publications

Chan JM, Quintanal-Villalonga Á, Gao VR, Xie Y, Allaj V, Chaudhary O,
Masilionis I, Egger J, Chow A, Walle T, Mattar M, Yarlagadda DVK, Wang JL, Uddin
F, Offin M, Ciampricotti M, Qeriqi B, Bahr A, de Stanchina E, Bhanot UK, Lai WV,
Bott MJ, Jones DR, Ruiz A, Baine MK, Li Y, Rekhtman N, Poirier JT, Nawy T, Sen
T, Mazutis L, Hollmann TJ, Pe’er D, Rudin CM. Signatures of plasticity,
metastasis, and immunosuppression in an atlas of human small cell lung cancer.
Cancer Cell. 2021 Nov 8;39(11) 

Chow A, Schad S, Green MD, Hellmann MD, Allaj V, Ceglia N, Zago G, Shah NS,
Sharma SK, Mattar M, Chan J, Rizvi H, Zhong H, Liu C, Bykov Y, Zamarin D, Shi H,
Budhu S, Wohlhieter C, Uddin F, Gupta A, Khodos I, Waninger JJ, Qin A, Markowitz
GJ, Mittal V, Balachandran V, Durham JN, Le DT, Zou W, Shah SP, McPherson A,
Panageas K, Lewis JS, Perry JSA, de Stanchina E, Sen T, Poirier JT, Wolchok JD,
Rudin CM, Merghoub T. Tim-4+ cavity-resident macrophages impair anti-
tumor CD8+ T cell immunity. Cancer Cell. 2021 Jul
12;39(7)

Ruscetti M, Morris JP 4th, Mezzadra R, Russell J, Leibold J, Romesser PB,
Simon J, Kulick A, Ho YJ, Fennell M, Li J, Norgard RJ, Wilkinson JE, Alonso-
Curbelo D, Sridharan R, Heller DA, de Stanchina E, Stanger BZ, Sherr CJ, Lowe
SW. Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities
in Pancreas Cancer. Cell. 2020 Apr 16;181(2):424-441.e21. Epub 2020 Mar 31. Erratum in: Cell. 2021 Sep
2;184(18)

Zhao Y, Murciano-Goroff YR, Xue JY, Ang A, Lucas J, Mai TT, Da Cruz Paula AF,
Saiki AY, Mohn D, Achanta P, Sisk AE, Arora KS, Roy RS, Kim D, Li C, Lim LP, Li
M, Bahr A, Loomis BR, de Stanchina E, Reis-Filho JS, Weigelt B, Berger M, Riely
G, Arbour KC, Lipford JR, Li BT, Lito P. Diverse alterations associated with
resistance to KRAS(G12C) inhibition. Nature. 2021 Nov;599(7886)  

Zhang Z, Karthaus WR, Lee YS, Gao VR, Wu C, Russo JW, Liu M, Mota JM, Abida
W, Linton E, Lee E, Barnes SD, Chen HA, Mao N, Wongvipat J, Choi D, Chen X, Zhao
H, Manova-Todorova K, de Stanchina E, Taplin ME, Balk SP, Rathkopf DE, Gopalan
A, Carver BS, Mu P, Jiang X, Watson PA, Sawyers CL. Tumor Microenvironment-
Derived NRG1 Promotes Antiandrogen Resistance in Prostate Cancer. Cancer Cell.
2020 Aug 10;38(2)  

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People

Elisa de Stanchina

Director

Members

Juan (Jane) Qiu, BS
Juan (Jane) Qiu

Senior Research Assistant

Huiyong Zhao, MD
Huiyong Zhao

Research Specialist

Julia Zaccaria

Research Technician

Santosh Adiraju

PK/GLP Manager

Phoebe Bacchus
Phoebe Bacchus

Senior Research Technician

Sydney Bowker
Sydney Bowker

Research Assistant

Qing Chang, PhD
Qing Chang

Scientific Research Lead

Kevin Chen
Kevin Chen

Research Assistant

Xiaoping Chen
Xiaoping Chen

Senior Research Assistant

Ana Crawford
Ana Crawford

Lead Research Admin Assistant

Olimpia Gavaudan

Research Technician

Idollia Gunpot

Research Technician

Sabrina Jezerca

Clinical Research Coordinator

Inna Khodos
Inna Khodos

Senior Research Assistant

Amanda Kulick

Supervisor

Jake Lee

Clinical Research Coordinator

Jeanine Lisanti

Project Coordinator

Laura Liu

QA/GLP Manager

Gisette Ochoa

Clinical Research Coordinator

Besnik Qeriqi

Supervisor

Sumaia Tarafdar

Clinical Research Coordinator

Morgan Temple

Senior Research Technician

Michael Tribuzio

Research Technician

Michael Trombetta

Research Technician

Riley Williams

Senior Research Technician

Open Positions

To learn more about available postdoctoral opportunities, please visit our Career Center

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