Human Oncology & Pathogenesis Program

The Charles Sawyers Lab

Research

Dr. Charles Sawyers
Charles L. Sawyers, MD
Investigator, Howard Hughes Medical Institute; Marie-Josée and Henry R. Kravis Chair in Human Oncology and Pathogenesis; Chair, Human Oncology and Pathogenesis Program

Dr. Sawyers is an HHMI Investigator searching for molecularly targeted approaches to treat cancer. He has identified cell signaling components critical to the growth of cancer cells in chronic myeloid leukemia, prostate and other cancers, resulting in the development of multiple FDA-approved inhibitors in clinical use today.

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The Charles Sawyers Lab

Publications Highlights

The neuroendocrine transition in prostate cancer is dynamic and dependent on ASCL1. Romero R, Chu T, González-Robles TJ, Smith P, Xie Y, Kaur H, Yoder S, Zhao H, Mao C, Kang W, Pulina MV, Lawrence KE, Gopalan A, Zaidi S, Yoo K, Choi J, Fan N, Gerstner O, Karthaus WR, DeStanchina E, Ruggles KV, Westcott PMK, Chaligné R, Pe’er D, Sawyers CL. bioRxiv [Preprint]. 2024 Apr 11:2024.04.09.588557. doi: 10.1101/2024.04.09.588557. PMID: 38645223 Free PMC article. Preprint.

Lineage plasticity in prostate cancer depends on JAK/STAT inflammatory signaling. Chan JM, Zaidi S, Love JR, Zhao JL, Setty M, Wadosky KM, Gopalan A, Choo ZN, Persad S, Choi J, LaClair J, Lawrence KE, Chaudhary O, Xu T, Masilionis I, Linkov I, Wang S, Lee C, Barlas A, Morris MJ, Mazutis L, Chaligne R, Chen Y, Goodrich DW, Karthaus WR, Pe’er D, Sawyers CL. Science. 2022 Sep 9;377(6611):1180-1191. doi: 10.1126/science.abn0478. Epub 2022 Aug 18. PMID: 35981096 Free PMC article.

Tumor Microenvironment-Derived NRG1 Promotes Antiandrogen Resistance in Prostate Cancer. Zhang Z, Karthaus WR, Lee YS, Gao VR, Wu C, Russo JW, Liu M, Mota JM, Abida W, Linton E, Lee E, Barnes SD, Chen HA, Mao N, Wongvipat J, Choi D, Chen X, Zhao H, Manova-Todorova K, de Stanchina E, Taplin ME, Balk SP, Rathkopf DE, Gopalan A, Carver BS, Mu P, Jiang X, Watson PA, Sawyers CL. Cancer Cell. 2020 Aug 10;38(2):279-296.e9. doi: 10.1016/j.ccell.2020.06.005. Epub 2020 Jul 16. PMID: 32679108 Free PMC article.

Regenerative potential of prostate luminal cells revealed by single-cell analysis. Karthaus WR, Hofree M, Choi D, Linton EL, Turkekul M, Bejnood A, Carver B, Gopalan A, Abida W, Laudone V, Biton M, Chaudhary O, Xu T, Masilionis I, Manova K, Mazutis L, Pe’er D, Regev A, Sawyers CL. Science. 2020 May 1;368(6490):497-505. doi: 10.1126/science.aay0267. PMID: 32355025 Free PMC article.

FOXA1 mutations alter pioneering activity, differentiation and prostate cancer phenotypes. Adams EJ, Karthaus WR, Hoover E, Liu D, Gruet A, Zhang Z, Cho H, DiLoreto R, Chhangawala S, Liu Y, Watson PA, Davicioni E, Sboner A, Barbieri CE, Bose R, Leslie CS, Sawyers CL. Nature. 2019 Jul;571(7765):408-412. doi: 10.1038/s41586-019-1318-9. Epub 2019 Jun 26. PMID: 31243370 Free PMC article.

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People

Dr. Charles Sawyers

Charles L. Sawyers, MD

Investigator, Howard Hughes Medical Institute; Marie-Josée and Henry R. Kravis Chair in Human Oncology and Pathogenesis; Chair, Human Oncology and Pathogenesis Program

  • Human Oncology and Pathogenesis Program Chair Charles Sawyers develops molecularly targeted cancer therapy.
  • MD, Johns Hopkins University School of Medicine
sawyersc@mskcc.org
Email Address
646-888-2138
Office Phone

Members

Wassim Abida, MD, PhD
Associate Member
Brett Carver, MD, PhD
Associate Attending
Zhendong Cao
Research Fellow - HHMI
Research Scholar
Agnieszka Chryplewicz
Research Scholar
Teng Han
Research Associate
Emmet Huang-Hobbs
Research Scholar
Harmanpreet Kaur
Research Technician
Zahra Khan
Research Technician
Young Sun Lee
MD-PhD Candidate
Ninghui Mao
Laboratory Manager
Kyrie Pappas
Senior Research Scientist
Rodrigo Romero
Research Associate
Zhen Sun
Research Associate
Philip Watson, PhD
Assistant Lab Member
Minna Balbas
Senior Director, Clinical Science, Loxo Oncology at Lilly, San Francisco, CA
Rohit Bose, MD, PhD
Research Fellow
Fiona Chen, MD
Graduate Student
Daniel C. Danila, MD
Medical Oncology Fellow
Senior Research Scientist
Phil Iaquinta, PhD
Senior Research Scientist
Ping Mu, PhD
Research Fellow
Senior Research Scientist
Research Technician
Neel Shah
Associate Director, Astra Zeneca
Research Technician
MD/PhD Student
John Wongvipat, BS
Research Lab Manager
Research Fellow
Zeda Zhang
Damon Runyon Cancer Research Foundation Fellow at Memorial Sloan Kettering Cancer Center, New York, NY
Dominique Abita
Assistant to the Chairman
Weiran Feng, Research Fellow
Assistant Professor at Fox Chase Cancer Center
Aura Agudelo Rivera
Research Technician
Zhen Cao
NE WGS Graduate Student
Danielle Choi
Senior Animal Husbandry Technician
Tara Guclu
Assistant to Chairman
Elizabeth Hoover, BS
Senior Research Technician
Taslima Ishmael, BS
Research Technician
Research Technician
Wouter Karthaus, PhD
Research Assistant
Daniel (Henry) Kates
Research Technician
Justin Laclair
Research Technician
Matthew Lange
Research Technician
Kayla Lawrence, BS
Senior Research Technician
Eugine Lee, PhD
Research Fellow
Eliot Linton
Research Technician
Jillian Love
Research Technician
Tejasveeta Nadkarni
Senior Research Technician
NE WGS Graduate Student
Abbas Nazir
NE WGS Student
Research Associate
Research Technician
J. Joshua Smith
Associate Member
Perianne Smith
Senior Research Technician
Patrick Sullivan, BS
Research Technician
Dr. Marie Will
Assistant Attending
David Wise, MD, PhD
Research Fellow
Graduate Research Assistant
Chao Wu
Senior Research Scientist
MSKCC Bridge Program Scholar
Research Fellow
Research Technician
Elizabeth Wasmuth
Assistant Professor, UT Health San Antonio, San Antonio, TX
Research Fellow
Research Technician

Achievements

  • NCI Alfred G. Knudson Award in Cancer Genetics (2020)
  • STAT Biomedical Innovation Award (2019)
  • AACR Princess Takamatsu Memorial Lectureship and Award (2019)
  • The Scheele Award, Swedish Academy of Pharmaceutical Sciences (2017)
  • American Cancer Society Medal of Honor (2017)
  • BBVA Foundation Frontiers of Knowledge Award (2015)
  • Breakthrough Prize in Life Sciences (2013)
  • Breakthrough Prize in Life Sciences (2013)
  • Science of Oncology Award, American Society of Clinical Oncology (2013)
  • Stanley J. Korsmeyer Award, American Society of Clinical Investigation (2011)
  • Member, National Academy of Sciences (2010)
  • Lasker-DeBakey Clinical Medical Research Award (2009)
  • Lasker~DeBakey Clinical Medical Research Award, Lasker Foundation (2009)
  • Dorothy Landon-AACR Prize for Translational Cancer Research, American Association for Cancer Research (2009)
  • Member, Institute of Medicine of the National Academies (2008)
  • David A. Karnofsky Memorial Award, American Society of Clinical Oncology (2005)

Open Positions

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Disclosures

Members of the MSK Community often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community. These activities outside of MSK further our mission, provide productive collaborations, and promote the practical application of scientific discoveries.

MSK requires doctors, faculty members, and leaders to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public. Not all disclosed interests and relationships present conflicts of interest. MSK reviews all disclosed interests and relationships to assess whether a conflict of interest exists and whether formal COI management is needed.

Charles L. Sawyers discloses the following relationships and financial interests:

  • Arsenal IO Canada Parent, Inc.
    Equity; Professional Services and Activities
  • BeiGene, Ltd.
    Equity; Professional Services and Activities
  • Blueprint Medicines
    Professional Services and Activities
  • Column Group
    Equity; Professional Services and Activities
  • Diaprost AB
    Intellectual Property Rights
  • Foghorn Therapeutics
    Equity; Professional Services and Activities
  • Housey Pharmaceutical
    Equity; Professional Services and Activities
  • Nextech Venture, LTD
    Equity; Professional Services and Activities
  • Novartis
    Equity
  • Oric Pharmaceuticals
    Equity; Intellectual Property Rights; Professional Services and Activities
  • PMV Pharma
    Equity; Professional Services and Activities

The information published here is a complement to other publicly reported data and is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.


This page and data include information for a specific MSK annual disclosure period (January 1, 2024 through disclosure submission in spring 2025). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at ecoi@mskcc.org.


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