Human Oncology & Pathogenesis Program

The Kojo Elenitoba-Johnson and Megan Lim Lab

Research

Kojo S. Elenitoba-Johnson is the Chair of the Department of Pathology and Laboratory Medicine and a physician-scientist. Dr. Elenitoba-Johnson’s research focuses on the role of genomic and proteomic alterations in the pathogenesis of lymphomas.

Dr. Megan S. Lim is the Director of the Lymphoma Translational Research Program and Director of the Biofluid Biobank. Dr. Lim is a hematopathologist-scientist who studies the role of genomic and proteomic alterations in the pathogenesis of lymphoma.

The research interests of the Elenitoba-Johnson-Lim lab encompass genomic and functional proteomic approaches to discover novel mechanisms of lymphoma pathogenesis; development of conditional murine models for investigating the role of oncogenes and tumor suppressor genes in lymphocyte development and lymphomas genesis and translational research utilizing innovative genomic and mass spectrometry-based approaches focused on identification of novel genomic and proteomic targets for diagnostic and therapeutic applications. 

Research Projects

Lap PIs

Dr. Elenitoba- Johnson and Dr. Megan Lim

Featured News

Memorial Sloan Kettering Physician-Scientists Elected to the Prestigious National Academy of Medicine
Memorial Sloan Kettering Physician-Scientists Elected to the Prestigious National Academy of Medicine
Luis Diaz Jr., MD, Head of the Division of Solid Tumor Oncology, and incumbent of the Grayer Family Chair, and Kojo S.J. Elenitoba-Johnson, MD, Chair of the Department of Pathology and Laboratory Medicine, Member in the Human Oncology Pathogenesis Program (HOPP), and the incumbent of the James Ewing Alumni Chair of Pathology at Memorial Sloan Kettering Cancer Center (MSK), have been elected to the National Academy of Medicine (NAM), one of the highest honors bestowed upon scientists worldwide.
See Dr. Kojo Elenitoba-Johnson, the inaugural Chair of the MSK Department of Pathology and Laboratory Medicine.
Pinpoint Accuracy: How Dr. Elenitoba-Johnson Helps Lead the Diagnosis of Cancer at MSK
Learn about Dr. Kojo Elenitoba-Johnson, who leads teams of Memorial Sloan Kettering experts in interpreting lab tests and diagnosing cancer as the inaugural Chair of the MSK Department of Pathology and Laboratory Medicine. He is also a member in the Human Oncology and Pathogenesis Program.

Publications Highlights

Sande CM, Wu R, Yang G, Sussman RT, Bigdeli A, Rushton C, Chitturi A, Patel J, Szankasi P, Morrissette JJD, Lim MS, Elenitoba-Johnson KSJ.  Rapid and Automated Semiconductor-Based Next-Generation Sequencing for Simultaneous Detection of Somatic DNA and RNA Aberrations in Myeloid Neoplasms.  J Mol Diagn. 2022 Dec 8:S1525-1578(22)00342-7. doi: 10.1016/j.jmoldx.2022.11.005. Online ahead of print.

Rolland DCM, Basrur V, Jeon YK, McNeil-Schwalm C, Fermin D, Conlon KP, Zhou Y, Ng SY, Tsou C-C, Brown NA, Thomas DG,. Bailey NG, Omenn GS, Nesvizhskii AI, Weinstock DM, Faryabi RB, Lim MS, and Elenitoba-Johnson KSJ.  Functional proteogenomics reveals biomarkers and therapeutic targets in lymphoid cancer.  Proc Natl Acad Sci USA. 2017; Jun 20:114(25):6581-86. doi: 10.1073/pnas. Epub 2017 Jun 12.

Kiel M, Sahasrabuddhe A, Rolland D, Velusamy T, Chung F, Schaller M, Bailey N, Betz B, Miranda R, Porcu P, Byrd, JL, Medeiros J, Kunkel S, Bahler D, Lim MS, and Elenitoba-Johnson KSJ.  Genomic analyses reveal recurrent mutations in epigenetic modifiers and JAK-STAT pathway in Sézary Syndrome.  Nature Communications 2015; Sep 29;6:8470. PMCID: PMC4598843.

Brown NA, Furtado LV, Betz BL, Kiel MJ, Weigelin HC, Lim MS, Elenitoba-Johnson KS.  High prevalence of somatic MAP2K1mutations in BRAF V600E-negative Langerhans cell histiocytosis.  Blood 2014; Sep 4;124(10):1655-8.

Kiel MJ, Velusamy T, Betz BL, Zhao L, Weigelin HG, Chiang MY, Huebner-Chan DR, Bailey NG, Yang DT, Bhagat G, Miranda RN, Bahler DW, Medeiros LJ, Lim MS, Elenitoba-Johnson KSJ. Whole-genome sequencing identifies recurrent somatic NOTCH2 mutations in splenic marginal zone lymphoma. J Exp Med 2012; 209:1553-65. PMCID: 3428949

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People

Adiya Ali
Research Technician
Jonathan Bermeo
Lab Manager
Kojo S.J. Elenitoba-Johnson, MD
Kojo S.J. Elenitoba-Johnson
Principal Investigator; Chair, Department of Pathology and Laboratory Medicine
Donnae Farquharson
Administrative Assistant
Jack (Huan-Chang) Liang
Research Fellow
Megan So-Young Lim
Megan So-Young Lim
Director, Lymphoma Translational Research Program; Director of the Biofluid Biobank
Jose Luis Marin Rubio
Jose Luis Marin Rubio
Research Associate
Loredana Moro
Loredana Moro
Scientific Research Lead
Alex Nanchanatt
Clinical Fellow
Prasath Pararajalingam
Research Fellow
Paurnima Patil
Paurnima Patil
Research Fellow
Vijendra Ramlall
Computational Biologist
Anagh Sahasrabuddhe
Assistant Lab Member
Janine Trombke
Research Fellow
Robert Williams
Clinical Fellow
Rui Wu
Senior Research Scientist
Xia Yang
Research Assistant
Kaiyu Ma
Senior Research Scientist
Sarah Qadir
Laboratory Administrator
Rie Uni
Research Fellow

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