The Juan Osorio Lab

The Osorio lab investigates the mechanisms underlying antibody-mediated immunity, and how we can leverage these insights to develop durable and effective antibody-based immunotherapies. Our research focuses on harnessing the untapped potential of the innate immune system – particularly the myeloid compartment – to drive antitumor immunity, especially in cancers that are refractory to current T cell-centric approaches. We use an integrated approach that combines humanized mouse models, antibody engineering, and high-dimensional immune profiling to dissect the cellular and molecular pathways behind therapeutic antibody activity. A major emphasis of our work is placed on how antibodies reprogram myeloid cell function, enhance crosstalk with adaptive immunity, and reshape the tumor microenvironment to support sustained immune responses. By integrating mechanistic immunology with therapeutic development, we aim to inform the rational design, optimization, and evaluation of next-generation antibody therapeutics capable of delivering durable clinical benefit.

Projects

• Mechanisms of antibody-mediated antitumor immunity
• Regulation of myeloid cell effector function
• Expanding the therapeutic window of immunomodulatory antibodies
• Translating myeloid-targeted therapies into the clinic