Memorial Hospital Research Laboratories

The Martin Weiser Lab

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Research

Pictured: Martin R. Weiser
Martin R. Weiser, MD

Our research investigates the natural history, molecular biology, and treatment response of cancers of the rectum and colon with the goal of personalizing therapy to reduce treatment toxicity, increase survival, and improve post-treatment quality of life.  We have built and tested clinical calculators using clinical, pathologic and molecular features to improve prognostication and better understand tumor biology.  Our contributions to advancing our understanding of colorectal cancer biology and improving colorectal cancer treatment include refinement of neoadjuvant chemotherapy with selective use of radiotherapy, identification of constitutive activation of receptor tyrosine kinases, and characterization of drivers of tumor-infiltrating lymphocytes. 

Publications Highlights

Judge SJ, Malekzadeh P, Corines MJ, Gollub MJ, Horvat N, Gonen M, Saltz L, Cercek A, Romesser P, Crane C, Shia J, Wei I, Widmar M, Pappou E, Nash GM, Smith JJ, Paty PB, Garcia-Aguilar J, Weiser MR. Watch and wait in rectal cancer patients with residual mucin on magnetic resonance imaging following neoadjuvant therapy. JNCI: Journal of the National Cancer Institute. 2024,Nov;116:1761-1766. PMCID:PMC11542991

Bektas AB, Hakki L, Khan A, Widmar M, Wei IH, Pappou E, Smith JJ, Nash GM, Paty PB, Garcia-Aguilar J, Cercek A, Stadler Z, Segal NH, Shia J, Gonen M, Weiser MR. Clinical calculator for predicting freedom from recurrence after resection of stage I-III colon cancer in patients with microsatellite instability. JCO Clinical Cancer Informatics. 2024,Sep;8:e2300233. PMCID:PMC11323037

Hakki L, Khan A, Do E, Gonen M, Firat C, Vakiani E, Shia J, Widmar M, Wei IH, Smith JJ, Pappou EP, Nash GM, Paty PB, Garcia-Aguilar J, Weiser MR. Tumour deposits are independently associated with recurrence in colon cancer. Colorectal Disease. 2024,Mar;26:459-465. PMCID:PMC10981558

Khan A, Thompson HM, Hsu M, Widmar M, Wei IH, Pappou E, Smith JJ, Nash GM, Paty PB, Garcia-Aguilar J, Shia J, Gönen M, Weiser M. Validation of a clinical calculator predicting freedom from colon cancer recurrence after surgery on the basis of molecular and clinical variables . Diseases of the Colon and Rectum. 2024,Feb;67:240-245. PMCID:PMC10843082

Hakki L, Khan A, Gonen M, Stadler Z, Segal NH, Shia J, Widmar M, Wei IH, Smith JJ, Pappou EP, Nash GM, Paty PB, Garcia-Aguilar J, Weiser MR. Lymph node metastases and associated recurrence-free survival in microsatellite stable and unstable colon cancer. Annals of Surgical Oncology. 2023,Dec;30:8487-8494. PMCID:PMC10842299

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People

Pictured: Martin R. Weiser

Martin R. Weiser, MD

  • Physician-scientist Martin Weiser investigates the mechanisms underlying tumor spread and metastasis and how these mechanisms could be targeted.
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Physician profile

Members

Tommy Chen

Senior Research Technician

Matthew Hill

Research Fellow

Lab Alumni
Thomas Bachleitner-Hofmann

Research Fellow

Peirong Ding

Research Fellow

Todd Francone

Research Fellow

Lauren Tufts

Research Fellow

Lynn Hakki

Research Fellow

Rosa Jimenez

Research Fellow

Romane Joseph

Research Fellow

Ajaratu Keshinro

Research Fellow

Asama Khan

Research Fellow

Hyaehwan Kim

Research Fellow

Tsuyoshi Konishi

Research Fellow

Ron Landmann

Research Fellow

David Liska

Research Fellow

Lauren Matthews

Research Fellow

Hak Mien Quah

Research Fellow

Campbell Roxburgh

Research Fellow

Mark Sun

Research Fellow

Thikhamporn Tawantanakorn

Research Fellow

Atthaphorn Trakarnsanga

Research Fellow

Lab Affiliations

Open Positions

To learn more about available postdoctoral opportunities, please visit our Career Center

To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs

Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Martin R. Weiser discloses the following relationships and financial interests:

  • UptoDate
    Intellectual Property Rights; Professional Services and Activities

The information published here is a complement to other publicly reported data and is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2023 through disclosure submission in spring 2024). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at ecoi@mskcc.org.


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