Hospital Research Teams
The Corey Weistuch Lab
Overview
Tumors and their drug sensitivities evolve over time, leading to drug resistance, metastasis, and ultimately, treatment failure. We are focused on developing mathematical models to understand this evolutionary process through the integration of genomic, transcriptomic, and radiomic data. Central to this approach is the recognition that tumors occupy a finite spectrum of functional states, each characterized by distinct treatment sensitivities and metastatic tendencies that evolve over time and in response to therapy. Our research centers on two primary objectives:
- developing innovative mathematical tools to identify cancer phenotype drivers
- precision modeling of cancer evolution and site-specific metastatic dissemination
By leveraging our interdisciplinary expertise in mathematics and biology, we collaborate closely with experimental biologists and clinicians to ensure that our computational predictions are effectively translated into tangible clinical applications and trials.
