Saha N, Chan E, Mendoza RP, Romin Y, Tipping MJ, Nikolov DB. (2025). Antibodies targeting ADAM17 reverse neurite outgrowth inhibition by myelin-associated inhibitors. Life Science Alliance, 8(6):e202403126. doi: 10.26508/lsa.202403126. PMID: 40132887; PMCID: PMC11938383

Saha N, Lee SG, Brockmann EC, de la Cruz MJ, Goldgur Y, Mendoza RP, Stanchina E, Love TM, Marvald J, Xu Y, Xu K, Himanen JP, Lamminmäki U, Veach D, Nikolov DB. (2024) Fully human monoclonal antibody targeting the cysteine-rich substrate-interacting region of ADAM17 on cancer cells. Biomed Pharmacother. 2024 Nov;180:117605. doi: 10.1016/j.biopha.2024.117605. Epub 2024 Oct 25. PMID: 39461016; PMCID: PMC11787792

Shi X, Lingerak R, Herting CJ, Ge Y, Kim S, Toth P, Wang W, Brown BP, Meiler J, Sossey-Alaoui K, Buck M, Himanen J, Hambardzumyan D, Nikolov DB^*, Smith AW^*, Wang B^*. (joint corresponding authors). (2023) Time-resolved live-cell spectroscopy reveals EphA2 multimeric assembly. Science. 2023 Dec;382(6674):1042-1050. doi: 10.1126/science.adg5314. Epub 2023 Nov 16. PMID: 37972196; PMCID: PMC11114627

Xu K, Wu Z, Renier N, Antipenko A, Tzvetkova-Robev D, Xu Y, Minchenko M, Nardi-Dei V, Rajashankar KR, Himanen J, Tessier-Lavigne M, Nikolov DB. (2014). Structures of netrin-1 bound to two receptors provide insight into its axon guidance mechanism. Science, 344(6189): 1275-1279. PMID: 24876346; PMCID: PMC4369087

Xu K, Olsen O, Tzvetkova-Robev D, Tessier-Lavigne M, Nikolov DB. (2015). The crystal structure of DR6 in complex with the amyloid precursor protein provides insight into death receptor activation. Genes Dev, 29:1-6. PMID: 25838500; PMCID: PMC4403255

Saha N, Baek DS, Mendoza RP, Robev D, Xu Y, Goldgur Y, De La Cruz MJ, de Stanchina E, Janes PW, Xu K, Dimitrov DS, Nikolov DB. (2023). Fully human monoclonal antibody targeting activated ADAM10 on colorectal cancer cells. Biomed Pharmacother. 161:114494. PMID: 36917886; PMCID: PMC10499537

Xu K, Tzvetkova-Robev D, Xu Y, Goldgur Y, Chan YP, Himanen JP, Nikolov DB. (2013). Insights into Eph receptor tyrosine kinase activation from crystal structures of the EphA4 ectodomain and its complex with ephrin-A5. Proc Natl Acad Sci USA, 110(36): 14634-9. PMID: 23959867; PMCID: PMC3767517

Yu X, Seegar TC, Dalton AC, Tzvetkova-Robev D, Goldgur Y, Rajashankar KR, Nikolov DB^*, Barton WA^*. (2013). Structural basis for angiopoietin-1-mediated signaling initiation. Proc Natl Acad Sci USA, 110(18): 7205-10. PMID: 23592718; PMCID: PMC3645508

Xu K, Chan YP, Bradel-Tretheway B, Akyol-Ataman Z, Zhu Y, Dutta S, Yan L, Feng Y, Wang LF, Skiniotis G, Lee B, Zhou ZH, Broder CC, Aguilar HC, Nikolov DB. (2015). Crystal Structure of the Pre-fusion Nipah Virus Fusion Glycoprotein Reveals a Novel Hexamer-of-Trimers Assembly. PLoS Pathog, 8; 11(12): e1005322, PMID: 26646856; PMCID: PMC4672880

Atapattu L, Saha N, Chheang C, Eissman MF, Xu K, Vail ME, Hii L, Llerena C, Liu Z, Horvay K, Abud HE, Kusebauch U, Moritz RL, Ding BS, Cao Z, Rafii S, Ernst M, Scott AM, Nikolov DB, Lackmann M, Janes PW. (2016). An activated form of ADAM10 is tumor selective and regulates cancer stem-like cells and tumor growth. J Exp Med, 213(9): 1741-57. PMID: 27503072; PMCID: PMC4995075

Seegar TCM, Killingsworth LB, Saha N, Meyer PA, Patra D, Zimmerman B, Janes PW, Rubinstein E, Nikolov DB, Skiniotis G, Kruse AC, Blacklow SC. (2017). Structural Basis for Regulated Proteolysis by the α-Secretase ADAM10. Cell, 171(7):1638-1648., PMID: 29224781; PMCID: PMC5773094

Reviews

Saha N, Robev D, Himanen JP, Nikolov DB. (2019). ADAM proteases: Emerging role and targeting of the non-catalytic domains. Cancer Lett., 467:50-57. PMID: 31593799; PMCID: PMC7485987

Barton WA, Dalton AC, Seegar TC, Himanen JP, and Nikolov DB. (2014). Tie2 and Eph Receptor Tyrosine Kinase Activation and Signaling, Cold Spring Harbor Perspectives in Biology: “Signaling by Receptor Tyrosine Kinases” edited by Joseph Schlessinger and Mark A. Lemmon, Cold Spring Harbor Laboratory Press, ISBN978-1-936113-33-0, pages 287-303. PMID: 24478383; PMCID: PMC3949358

Nikolov DB, Xu K, Himanen JP. (2014). Homotypic receptor-receptor interactions regulating Eph signaling. Cell Adh Migr, 8(4): 360-5. PMID: 25530219; PMCID: PMC4594565