Developmental Biology Program

The Lorenz Studer Lab

Research

Pictured: Dr. Lorenz Studer
Lorenz Studer, MD
Director, Center for Stem Cell Biology

Our laboratory aims at exploiting recent advances in stem cell biology to develop radically new therapies for degenerative disease and cancer. The main focus in the lab is on the biology and application of human embryonic stem (ES) and human induced pluripotent (iPS) cells. Pluripotent stem cells can provide a truly unlimited source for deriving therapeutically relevant cell types for applications in human disease modeling or regenerative medicine.

View Lab Overview

Research Projects

Lorenz Studer Lab

Publications Highlights

Chan YH, Liu Z, Bastard P, Khobrekar N, Hutchison KM, Yamazaki Y, Fan Q, Matuozzo D, Harschnitz O, Kerrouche N, Nakajima K, Amin P, Yatim A, Rinchai D, Chen J, Zhang P, Ciceri G, Chen J, Dobbs K, Belkaya S, Lee D, Gervais A, Aydın K, Kartal A, Hasek ML, Zhao S, Reino EG, Lee YS, Seeleuthner Y, Chaldebas M, Bailey R, Vanhulle C, Lorenzo L, Boucherit S, Rozenberg F, Marr N, Mogensen TH, Aubart M, Cobat A, Dulac O, Emiroglu M, Paludan SR, Abel L, Notarangelo L, Longnecker R, Smith G, Studer L., Casanova JL, Zhang SY. Human TMEFF1 is a restriction factor for herpes simplex virus in the brain. Nature. 2024 Jul 24. doi: 10.1038/s41586-024-07745-x. PMID: 39048830 

Kim TW, Koo SY, Riessland M, Chaudhry F, Kolisnyk B, Cho HS, Russo MV, Saurat N, Mehta S, Garippa R, Betel D, Studer L. TNF-NF-κB-p53 axis restricts in vivo survival of hPSC-derived dopamine neurons. Cell. 2024 Jul 11;187(14):3671-3689.e23. doi: 10.1016/j.cell.2024.05.030. Epub 2024 Jun 11. PMID: 38866017 

Saurat N, Minotti AP, Rahman MT, Sikder T, Zhang C, Cornacchia D, Jungverdorben J, Ciceri G, Betel D, Studer L. Genome-wide CRISPR screen identifies neddylation as a regulator of neuronal aging and AD neurodegeneration. Cell Stem Cell. 2024 Aug 1;31(8):1162-1174.e8. doi: 10.1016/j.stem.2024.06.001. Epub 2024 Jun 24. PMID: 38917806 

de Luzy IR, Lee MK, Mobley WC, Studer L. Lessons from inducible pluripotent stem cell models on neuronal senescence in aging and neurodegeneration. Nat Aging. 2024 Mar;4(3):309-318. doi: 10.1038/s43587-024-00586-3. Epub 2024 Mar 1. PMID: 38429379  

Ciceri G, Baggiolini A, Cho HS, Kshirsagar M, Benito-Kwiecinski S, Walsh RM, Aromolaran KA, Gonzalez-Hernandez AJ, Munguba H, Koo SY, Xu N, Sevilla KJ, Goldstein PA, Levitz J, Leslie CS, Koche RP, Studer L. An epigenetic barrier sets the timing of human neuronal maturation. Nature. 2024 Jan 31. doi: 10.1038/s41586-023-06984-8. PMID: 38297124

View All Publications

People

Pictured: Dr. Lorenz Studer

Lorenz Studer, MD

Director, Center for Stem Cell Biology

  • The Studer laboratory investigates human stem cells as tools to understand normal and pathological development in the nervous system and to develop cell-based strategies for regenerative medicine.
  • MD, Universitat Bern
studerl@mskcc.org
Email Address
212-639-6126
Office Phone

Members

Lab Manager
Giridhar Anand
Research Fellow
Vittoria Bocchi
Research Associate
James Hackland
Senior Research Scientist
Luz Jubierre Zapater
Senior Research Scientist
Noopur Khobrekar
Research Fellow
Ryan Walsh, PhD
Senior Research Scientist
Leslie Weber, PhD
Research Scholar - NYSTEM Training Award at the CSCB
Donghe Yang
Research Fellow
Zhe Yang
Research Fellow - NYSTEM Training Award at the CSCB
Alessandro Evangelisti
Graduate Student
Graduate Student
Graduate Student
Graduate Student
Graduate Student
MSK Bridge Scholar
Kaylin Sevilla Lopez
Research Technician
Adrianne Nemchik
Research Technician
Danaysy Frias
Senior Administrative Assistant
Gabriele Ciceri, Ph.D.
Senior Research Scientist
Andrew Minotti
Graduate Student - currently: Research Scientist at Rumi Scientific
Nan Xu
Graduate Student - currently: Lead Scientist at NewBrain Biosciences
Research Technician - currently: PhD student, The Gerstner Sloan Kettering Graduate School of Biomedical Sciences
Nathalie Saurat, PhD
Senior Research Scientist - currently: Assistant Professor, Monash University. Melbourne, Australia
Berkiye Sonustun
Graduate Student - currently: Healthcare Consultant at PwC, Cyprus
Johannes Jungverdorben, PhD
Senior Research Scientist
Dylan Ritter
Research Scholar- currently: Science Director of the Dup15q Alliance
Research Technician - currently: Post-Bac Researcher, HSS (Donlin Lab)
Research Technician - currently: MD student, The Ohio State University College of Medicine
Param Amin
Research Technician - currently: PhD student, The Gerstner Sloan Kettering Graduate School of Biomedical Sciences
Alex Henderson
Program Manager - currently: Program Director at Mass General Hospital
Elisa Giacomelli
Research Associate - currently: Research Fellow, Neurological Clinical Research Institute at MGH/ Harvard
TaeWan Kim, PhD
Senior Research Scientist - currently: Assistant Professor at DGIST, Korea
So Yeon Koo
Graduate Student - currently: Postdoc, Narry Kim lab, South Korea
Polina Oberst, PhD
Research Associate - currently: Med School and Scientist at Brain & Life Institute, Bonn Germany
Yen Chun "Wenna" Chen
Research Technician - currently: PhD student, Albert Einstein College of Medicine
Jiayi Yuan
Graduate Student - currently: Equity Research Associate at RBC
Chelsea Rittenhouse
Graduate Student - currently: Research Scientist, Rumi Scientific
Isabelle de Luzy
Research Fellow - currently: Project Manager, FightMND
Yujie Fan
Graduate Student - currently: Postdoc Fellow, Caltech (V. Gradinaru lab)
Samantha Phillips
Graduate Student - currently: Psychiatry Resident, University of Miami/Jackson Health
Angela Pepe-Caprio
Lab Manager - currently: Operations Manager, Integrated Genomics Operation Core
Elizabeth L Calder, PhD
Senior Research Scientist - currently: Senior Scientist at DaCapo Brain Science
Arianna Baggiolini
Research Fellow - currently: Assistant Professor, IOR, Bellinzona & University of Zurich, Switzerland
Emiliano Hergenreder
Graduate Student - currently: Senior Scientist at Arc Institute
Oliver Härschnitz
Research Associate - currently: Research Group Leader at Human Technopole, Italy
Lab Technician - currently: MD/PhD student at Geisel School of Medicine at Dartmouth
Daniela Cornacchia, PhD
Postdoctoral Fellow - currently: Associate Principal Scientist at AstraZeneca, Sweden
Sun Young Chung
Lab Technician - currently: medical student, Harvard University
Sudha Guttikonda
Graduate Student - currently: Psychiatry Resident, Columbia University
Eveline Gutzwiller
Postdoctoral Fellow - currently: Neurology resident, Mount Sinai Medical School, New York, NY
Jason Tchieu
Postdoctoral Fellow - currently: Assistant Professor, Cincinnati Children’s Hospital, Cincinnati, OH
Scott J. Callahan
Graduate Student - currently: Senior Vice President, Director of Medical Strategy at Havas Health & You, New York, NY
Gustav Cederquist
Graduate Student – currently: Resident in Radiation Oncology, Memorial Sloan Kettering Cancer Center
Nadja Zeltner, PhD
Postdoctoral fellow – currently, Assistant Professor, University of Georgia
Yuchen Qi
Postdoctoral Fellow - currently: Consultant, The Boston Consulting Group
Postdoctoral Fellow – currently: Group leader, Helmholtz Zentrum, Munich, Germany
Faranak Fattahi, MS
Graduate Student - currently, Sandler Faculty Fellow, UCSF
Elsa Vera
Postdoctoral Fellow - currently: Senior Machine Learning Engineer - Digital Intelligence at JPMorgan Chase & Co.
Bastian Zimmer, PhD
Postdoctoral Fellow - currently: Group leader, Evotec, Hamburg, Germany
Mohamed Soliman
Medical Student, Weill Cornell - currently: Physician/Psychiatrist, Ann Arbor, Michigan
Sarah Kishinevsky
Graduate Student – currently, Director of the Dean's Entrepreneurship Lab at Weill Cornell
Postdoctoral Fellow - currently: Freelance Neurologist and Stem Cell Expert, Germany
Yosif Martin Ganat
Postdoctoral Fellow - currently: Research Investigator, Arvinas
Postdoctoral Fellow - currently Senior Scientist at Neurona Therapeutics Inc
Postdoctoral fellow - currently: Assistant Prof., Soonchunhyang University
Postdoctoral Fellow - currently, Senior Scientist at Amgen
Principal Scientist at AbbVie, Boston, MA
Research Fellow - currently, Course Instructor, American Museum of Natural History
Fabien Lafaille
PhD student – currently: CMC lead & Director, BlueRock Therapeutics
Senior Product Manager - Cancer Cell Model Thermo Fisher Scientific New York, NY
Graduate Student - currently: Principal Scientist, Discovery Biology
Postdoctoral Fellow - currently: Associate Prof., Johns Hopkins School of Medicine
Graduate Student - currently: Assistant Professor, The University of Texas at San Antonio
Postdoctoral fellow - Currently: Principal Investigator, Max Planck Institute for Molecular Genetics,
Postdoctoral fellow - currently: Assistant Prof., Helmholtz Institute
Tiziano Barberi
Postdoctoral Fellow - Currently: Associate Scientist, Texas BioMed Research Institute, SW National Primate Research Center
Mark J Tomishima, PhD
Currently, Sr. Director, CNS Bioprocess at BlueRock Therapeutics
Chair, Department of Neurosurgery; Theresa Feng Chair in Neurosurgical Oncology
Anselme Perrier
Postdoctoral Fellow - currently: Principal Investigator, iSTEM, INSERM, France
Hyesoo Kim
Currently, Assistant Professor at Johns Hopkins School of Medicine
Agnete Kirkeby
PhD student – currently, Associate Professor of Stem Cell Biology, University of Copenhagen, Denmark

Achievements

  • Member, National Academy of Medicine (2024)
  • Helis Foundation Prize for Parkinson’s disease and Neurodegenerative Research, John’s Hopkins University (2024)
  • ISSCR Achievement Award (2022)
  • ISSCR, Ernest McCulloch Memorial Lecture, Robert & Claire Pasarow Foundation Award (2019)
  • Jacob & Louise Gabbay Award in Biotechnology & Medicine (2018)
  • Ogawa-Yamanaka Stem Cell Prize, Gladstone Institutes (2017)
  • MacArthur Fellow (2015)
  • Member, American Society of Clinical Investigation (2014)
  • Annemarie Opprecht Parkinson Award, Annemarie Opprecht Foundation (2012)
  • Louise and Allston Boyer Young Investigator in Basic Research, Memorial Sloan Kettering Cancer Center (2005)

Lab News & Events

Upcoming event

Building Robust Models of Early Human Development

Memorial Sloan Kettering Cancer Center
Rockefeller Research Laboratories
430 East 67th Street
Room RRL-116
New York, NY 10065

Open Positions

To learn more about available postdoctoral opportunities, please visit our Career Center

To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs

Career Opportunities

Apply now

Get in Touch

Disclosures

Members of the MSK Community often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community. These activities outside of MSK further our mission, provide productive collaborations, and promote the practical application of scientific discoveries.

MSK requires doctors, faculty members, and leaders to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public. Not all disclosed interests and relationships present conflicts of interest. MSK reviews all disclosed interests and relationships to assess whether a conflict of interest exists and whether formal COI management is needed.

Lorenz Studer discloses the following relationships and financial interests:

  • BlueRock Therapeutics
    Intellectual Property Rights; Professional Services and Activities
  • DaCapo Brainscience, Inc.
    Equity; Professional Services and Activities (Uncompensated)
  • Fujifilm Cellular Dynamics, Inc.
    Intellectual Property Rights
  • Luxa Biotechnology, LLC
    Professional Services and Activities
  • Roche
    Professional Services and Activities
  • Rumi Scientific, Inc.
    Equity; Professional Services and Activities (Uncompensated)
  • Vita Therapeutics, Inc.
    Equity; Professional Services and Activities (Uncompensated)

The information published here is a complement to other publicly reported data and is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.


This page and data include information for a specific MSK annual disclosure period (January 1, 2024 through disclosure submission in spring 2025). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at ecoi@mskcc.org.


View all disclosures