Link to Finley Lab publications
Selected Publications
Intracellular metabolic gradients dictate dependence on exogenous pyruvate.
Jackson BT*, Montero AM*, Chakraborty S, Brunner JS, Arnold PK, Bridgeman AE, Todorova PK, Paras KI, Finley LWS. Nature Metabolism. 7: 1168-1182. 2025.
Amino acid intake strategies define pluripotent cell states.
Todorova PK, Jackson BT, Garg V, Paras KI, Chen Y, Baksh SC, Yan J, Hadjantonakis, A, Finley LWS. Nature Metabolism. 6: 127-140. 2024.
A non-canonical tricarboxylic acid cycle underlies cellular identity.
Arnold PK, Jackson BT, Paras KI, Brunner JS, Hart ML, Newsom OJ, Alibeckoff SP, Endress J, Drill E, Sullivan LB, Finley LWS. Nature. 2022 Mar;603(7901):477-481. doi: 10.1038/s41586-022-04475-w. Epub 2022 Mar 9. PMID: 35264789; PMCID: PMC8934290.
Extracellular serine controls epidermal stem cell fate and tumour initiation.
Baksh SC, Todorova PK, Gur-Cohen S, Hurwitz B, Ge Y, Novak JSS, Tierney MT, Dela Cruz-Racelis J, Fuchs E#, Finley LWS#. Nat Cell Biol. 2020 Jul;22(7):779-790. doi: 10.1038/s41556-020-0525-9. Epub 2020 May 25. Erratum in: Nat Cell Biol. 2020 Nov;22(11):1396. PMID: 32451440; PMCID: PMC7343604. (#co-corresponding author)
α-Ketoglutarate links p53 to cell fate during tumour suppression.
Morris JP 4th*, Yashinskie JJ*, Koche R, Chandwani R, Tian S, Chen CC, Baslan T, Marinkovic ZS, Sánchez-Rivera FJ, Leach SD, Carmona-Fontaine C, Thompson CB, Finley LWS#, Lowe SW#. Nature. 2019 Sep;573(7775):595-599. doi: 10.1038/s41586-019-1577-5. Epub 2019 Sep 18. PMID: 31534224. (*co-first, #co-corresponding)
Glutamine independence is a selectable feature of pluripotent stem cells.
Vardhana SA, Arnold PK, Rosen BP, Chen Y, Carey BW, Huangfu D, Fontaine CC, Thompson CB, Finley LWS. Nat Metab. 2019 Jul;1(7):676-687. doi: 10.1038/s42255-019-0082-3. Epub 2019 Jul 8. PMID: 31511848
Selected Review Articles
Metabolic regulation of the hallmarks of stem cell biology.
Jackson BT, Finley LWS. Cell Stem Cell. 31: 161-180. 2024.
What is cancer metabolism?
Finley LWS. Cell. 186: 1670-1688, 2023.
Regulation and function of the mammalian tricarboxylic acid cycle.
Arnold PK, Finley LWS. J Biol Chem. 2022 Dec 26:102838. doi: 10.1016/j.jbc.2022.102838. Epub ahead of print. PMID: 36581208.
Metabolic determinants of tumour initiation.
Brunner JS, Finley LWS. Nat Rev Endocrinol. 2022 Nov 29. doi: 10.1038/s41574-022-00773-5. Epub ahead of print. PMID: 36446897.
SnapShot: Cancer metabolism.
Brunner JS, Finley LWS. Mol Cell. 2021 Sep 16;81(18):3878-3878.e1. doi: 10.1016/j.molcel.2021.06.021. PMID: 34547243.
Metabolic Coordination of Cell Fate by α-Ketoglutarate-Dependent Dioxygenases.
Baksh SC, Finley LWS. Trends Cell Biol. 2021 Jan;31(1):24-36. doi: 10.1016/j.tcb.2020.09.010. Epub 2020 Oct 19. PMID: 33092942; PMCID: PMC7748998.
Metabolic signatures of cancer cells and stem cells.
Intlekofer AM, Finley LWS. Nat Metab. 2019 Feb;1(2):177-188. doi: 10.1038/s42255-019-0032-0. Epub 2019 Feb 11. PMID: 31245788