Max Wilkinson: Publications

Wilkinson ME, Li D, Gao A, Macrae RK, Zhang F
Phage-triggered reverse transcription assembles a toxic repetitive gene from a noncoding RNA.
Science. 2024 Apr 5;384(6690):61-67. doi: 10.1126/science.adj3563
PMID: 39208082

Wilkinson ME, Frangieh CJ, Macrae RK, Zhang F
Structure of the R2 non-LTR retrotransposon initiating target-primed reverse transcription.
Science. 2023 Apr 7;380(6640):eabn8990. doi: 10.1126/science.abn8990
PMID: 37023171

Edmonds KK, Wilkinson ME, Strebinger D, Chen H, Lash B, Schaefer CC, Zhu S, Liu D, Zilberzwige-Tal S, Ladha A, Walsh ML, Frangieh CJ, Vaz Reay NA, Macrae RK, Wang X, Zhang F
Structure and biochemistry-guided engineering of an all-RNA system for DNA insertion with R2 retrotransposons.
Nat Commun. 2025 Sep 27;16(1):6793. doi: 10.1038/s41467-024-43853-w
PMID: 40603868

Faure G*, Saito M*, Wilkinson ME*, Quinones-Olvera N, Xu P, Flam-Shepherd D, Kim S, Reddy N, Zhu S, Evgeniou L, Koonin EV, Macrae RK, Zhang F
TIGR-Tas: A family of modular RNA-guided DNA-targeting systems in prokaryotes and their viruses.
Science. 2025 Jul 5;381(6651):50-57. doi: 10.1126/science.ado2503
PMID: 40014690

Gao LA*, Wilkinson ME*, Strecker J*, Makarova KS, Macrae RK, Koonin EV, Zhang F
Prokaryotic innate immunity through pattern recognition of conserved viral proteins.
Science. 2022 Aug 5;377(6606):eabm4096. doi: 10.1126/science.abm4096
PMID: 35951700

Wilkinson ME*, Charenton C*, Nagai K*
RNA Splicing by the Spliceosome.
Annu Rev Biochem. 2020 Jun 20;89:359-388. doi: 10.1146/annurev-biochem-011520-104722
PMID: 31794245

Wilkinson ME, Fica SM, Galej WP, Norman CM, Newman AJ, Nagai K
Postcatalytic spliceosome structure reveals mechanism of 3’-splice site selection.
Science. 2017 Nov 17;358(6368):1283-1288. doi: 10.1126/science.aao6535
PMID: 29146871

Galej WP, Wilkinson ME, Fica SM, Oubridge C, Newman AJ, Nagai K
Cryo-EM structure of the spliceosome immediately after branching.
Nature. 2016 Sep 22;537(7619):197-201. doi: 10.1038/nature19316
PMID: 27459055