Pictured: Sergio Giralt

Sergio A. Giralt, MD

Bone Marrow Transplant Specialist & Cellular Therapist

Areas of Expertise

Conditions I Treat

  • Multiple myeloma and other plasma-cell diseases
  • Leukemia
  • Lymphoma

My Specialties

  • Bone marrow transplant
  • Stem cell transplant
  • Autologous stem cell transplant
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Dr. Giralt's Office Information
Languages: English & Spanish
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Get to Know Me

I am a board-certified hematologist-oncologist, and my clinical activity and research focus on stem cell transplantation for patients with blood disorders. I trained and worked for many years at the University of Texas M.D. Anderson Cancer Center, where I was Deputy Chair of the Department of Stem Cell Transplantation and Cellular Therapies. In May 2010, I joined the faculty of Memorial Sloan Kettering Cancer Center to lead the Adult Bone Marrow Transplant Service and served as Chief until February 2020.

My research focus has been on improving treatments for older patients who have acute and chronic leukemia. My colleagues and I pioneered the use of reduced-intensity conditioning regimens for older or more debilitated patients with blood cancers. Before this discovery, older patients with these diseases were rarely considered candidates for stem cell transplantation procedures using donor cells because of the toxic effects of high-dose chemotherapy. The development of these less intense and less toxic regimens has allowed us to perform transplants for older patients in a safe and effective manner and has changed the standard of care throughout the world. I plan to continue this research in the context of the pioneering T cell depletion techniques developed at Memorial Sloan Kettering. This new approach has dramatically reduced the risk of graft-versus-host disease, a serious complication of donor stem cell transplantation. Disease recurrence after transplantation remains an important cause of treatment failure, and I am a proponent of post-transplant maintenance therapies using a variety of targeted therapies, which we are continuing to explore at Memorial Sloan Kettering.

I am an expert in the treatment of multiple myeloma, a blood cancer that affects plasma cells (the cells that produce the antibodies that protect us against infections). My research in this area has focused on developing new conditioning regimens for autologous transplant, a treatment approach in which patients receive an infusion of their own stem cells or bone marrow following a course of high-dose chemotherapy, as well as developing strategies that will reduce “symptom burden” and make the treatment so tolerable that it can be done on an outpatient basis. Our goal is to deliver the most effective therapies with minimum symptom burden. I led the Myeloma Intergroup Committee of the Blood and Marrow Clinical Trials Network, which developed the current national study looking at the role of consolidation therapy after autologous stem cell transplant for patients with myeloma.

As a strong believer in collaborative science among large academic centers, I have been involved in many multi-institutional projects and until recently chaired the executive board of the Center for International Blood and Marrow Transplant Research. I am also the past chair of the steering committee of the Blood and Marrow Transplant Clinical Trials Network, a federally funded group that defines the research agenda for stem cell transplantation in the United States.

What I Do at MSK

I'm a bone marrow transplant specialist, which is a doctor with special training in bone marrow transplants.

A cellular therapy specialist is a doctor with special training in using cell therapies to treat health conditions such as cancer. Therapies can include chimeric antigen receptor (CAR) T cell therapy.

  • Deputy Division Head, Division of Hematologic Malignancies
  • Melvin Berlin Family Chair in Multiple Myeloma
  • Chief Medical Officer, MSK Direct
Areas of Expertise

Conditions I Treat

  • Multiple myeloma and other plasma-cell diseases
  • Leukemia
  • Lymphoma
  • Acute lymphocytic leukemia (ALL)
  • Acute myeloid leukemia (AML)
  • Chronic lymphocytic leukemia (CLL)
  • Chronic myeloid leukemia (CML)
  • Acute promyelocytic leukemia (APL)

My Specialties

  • Bone marrow transplant
  • Stem cell transplant
  • Autologous stem cell transplant
  • Chemotherapy
  • Clinical trials
Education & Honors

Education

  • MD, Universidad Central de Venezuela

Residencies

  • Internal Medicine - Good Samaritan Hospital

Fellowships

  • Medical Oncology - MD Anderson Cancer Center

Board Certifications

  • Internal Medicine
  • Hematology
  • Medical Oncology

Awards and Honors

  • Castle Connolly: America’s Top Doctor (2025)
  • Castle Connolly: America’s Top Doctor (2024)
  • Top Doctors New York Metro Area, Castle Connolly (2023)
  • Castle Connolly: America's Top Doctors (2023)
  • Castle Connolly: New York Magazine Top Doctors (2016-2020)

Insurance Information

Understanding your insurance options is an important part of managing your cancer care. We have relationships with many common healthcare providers and plans.

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If you don't have health insurance or are worried that your care may not be fully covered, our financial assistance programs may be able to help.

If you have questions about insurance, call us at 646-497-9176.

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Contact and Location

Office Phone
Location
New York, NY
David H. Koch Center for Cancer Care at Memorial Sloan Kettering Cancer Center
530 East 74th Street New York NY 10021
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Colleagues

Doctors at Memorial Sloan Kettering work as teams, with specialists from all different areas. This allows us to consider all your needs together, and to give you the best possible care.

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Clinical Trials

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Find a Clinical Trial for You

Memorial Sloan Kettering's doctors and scientists are constantly developing new treatments for cancer. MSK is typically running hundreds of clinical trials at a given time.

You may be able to participate in a clinical trial even if you are new to MSK. Search our online directory to find trial information and see more about who can participate.

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Research and Publications

Publications on PubMed

Visit PubMed for a full listing of Dr. Giralt’s journal articles. Pubmed is an online index of research papers and other articles from the US National Library of Medicine and the National Institutes of Health.

See all on PubMed

Disclosures

Members of the MSK Community often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community. These activities outside of MSK further our mission, provide productive collaborations, and promote the practical application of scientific discoveries.

MSK requires doctors, faculty members, and leaders to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public. Not all disclosed interests and relationships present conflicts of interest. MSK reviews all disclosed interests and relationships to assess whether a conflict of interest exists and whether formal COI management is needed.

Sergio A. Giralt discloses the following relationships and financial interests:

  • Amgen
    Professional Services and Activities
  • Celgene
    Professional Services and Activities
  • CSL Behring
    Professional Services and Activities
  • ExpertConnect
    Professional Services and Activities
  • GlaxoSmithKline
    Professional Services and Activities
  • Incyte
    Professional Services and Activities
  • Janssen Research & Development, LLC
    Professional Services and Activities
  • Karyopharm
    Professional Services and Activities
  • Kite Pharmaceuticals
    Professional Services and Activities
  • Novartis
    Professional Services and Activities
  • Omeros
    Professional Services and Activities
  • Pfizer, Inc.
    Professional Services and Activities
  • Physicians' Education Resource
    Professional Services and Activities
  • Sanofi US Services Inc.
    Professional Services and Activities
  • TRM Oncology
    Professional Services and Activities
  • Xcenda
    Professional Services and Activities

If you’re a patient at MSK and would like more information about your doctor’s external relationships, please talk with your doctor.

The information published here is a complement to other publicly reported data and is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2024 through disclosure submission in spring 2025). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at ecoi@mskcc.org.


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