Human Oncology & Pathogenesis Program

The David Solit Lab

Research

David B. Solit, MD

Co-Director, Marie-Josée & Henry R. Kravis Center for Molecular Oncology

Our research is based on the underlying hypothesis that the ability to inhibit an oncogenic pathway and block cancer growth will vary based on cell lineage and the complement of mutations within the tumor. To design rational therapeutic studies, we must define not only the spectrum of genetic changes within particular tumor types but also the mechanisms by which these alterations support tumor growth, survival, metastasis, and other hallmarks of cancer.

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Research Projects

Featured News

Finding Clues in Genes of ‘Exceptional Responders’

Physician-scientist David Solit was interviewed about exceptional responders, patients who defy all expectations by responding dramatically to a drug t...

Event

A student asks a question at last year’s "Major Trends” seminar.

A Sneak Preview of Our Annual “Major Trends” Seminar Live Webcast

Every year, MSK gives high school students and their teachers the opportunity to learn about cutting-edge biomedical research from our scientists.

Feature

Memorial Sloan Kettering is transforming our understanding and treatment of cancer in a myriad of ways.

Memorial Sloan Kettering Transforms Cancer Research and Care Delivery

Memorial Sloan Kettering’s vision is nothing less than to revolutionize the treatment of cancer. Learn about some of the ways we’re doing it.

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Publications Highlights

Xing F, Persaud Y, Pratilas CA, Taylor BS, Janakiraman M, She QB, Gallardo H, Liu C, Merghoub T, Hefter B, Dolgalev I, Viale A, Heguy A, De Stanchina E, Cobrinik D, Bollag G, Wolchok J, Houghton A, Solit DB. Concurrent loss of the PTEN and RB1 tumor suppressors attenuates RAF dependence in melanomas harboring (V600E)BRAF. Oncogene. 2012 Jan 26;31(4):446-57. doi: 10.1038/onc.2011.250. Epub 2011 Jul 4.

Poulikakos PI, Persaud Y, Janakiraman M, Kong X, Ng C, Moriceau G, Shi H, Atefi M, Titz B, Gabay MT, Salton M, Dahlman KB, Tadi M, Wargo JA, Flaherty KT, Kelley MC, Misteli T, Chapman PB, Sosman JA, Graeber TG, Ribas A, Lo RS, Rosen N, Solit DB. RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E). Nature. 2011 Nov 23;480(7377):387-90. doi: 10.1038/nature10662.

Hanrahan AJ, Schultz N, Westfal ML, Sakr RA, Giri DD, Scarperi S, Janakiraman M, Olvera N, Stevens EV, She QB, Aghajanian C, King TA, Stanchina Ed, Spriggs DR, Heguy A, Taylor BS, Sander C, Rosen N, Levine DA, Solit DB. Genomic complexity and AKT dependence in serous ovarian cancer. Cancer Discov. 2012 Jan;2(1):56-67. doi: 10.1158/2159-8290.CD-11-0170.

Misale S, Yaeger R, Hobor S, Scala E, Janakiraman M, Liska D, Valtorta E, Schiavo R, Buscarino M, Siravegna G, Bencardino K, Cercek A, Chen CT, Veronese S, Zanon C, Sartore-Bianchi A, Gambacorta M, Gallicchio M, Vakiani E, Boscaro V, Medico E, Weiser M, Siena S, Di Nicolantonio F, Solit D, Bardelli A. Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer. Nature. 2012 Jun 28;486(7404):532-6. doi: 10.1038/nature11156.

Iyer G, Hanrahan AJ, Milowsky MI, Al-Ahmadie H, Scott SN, Janakiraman M, Pirun M, Sander C, Socci ND, Ostrovnaya I, Viale A, Heguy A, Peng L, Chan TA, Bochner B, Bajorin DF, Berger MF, Taylor BS, Solit DB. Genome sequencing identifies a basis for everolimus sensitivity. Science. 2012 Oct 12;338(6104):221. doi: 10.1126/science.1226344. Epub 2012 Aug 23.

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People

David B. Solit, MD

Co-Director, Marie-Josée & Henry R. Kravis Center for Molecular Oncology

Physician-scientist David Solit studies human oncology and pathogenesis, genomics, oncogenes and tumor suppressors, cancer therapeutics, and clinical trials.
MD, University of Pennsylvania

solitd@mskcc.org: Email Address
View physician profile: Physician profile

Members

Alexis M. Jones

Research Lab Manager

Aphrothiti Hanrahan

Assistant Lab Member

Gopa Iyer

Assistant Attending, Genitourinary Oncology Service

Kwanghee Kim

Associate Attending Biologist

Paul (Sizhi) Gao

Scientific Research Lead

James Rodrigues

GSK Graduate Student

Josie (Jiaqian) Luo

Weill Cornell BCMB Graduate Student

Michelle (Xinran) Tang

Weill Cornell Graduate Student

Jordan Eichholz

Computational Biologist I

Hikmat A. Al-Ahmadie

Associate Attending Pathologist, Memorial Hospital

Cansu Yol

Senior Research Scientist

Merve Basar

Senior Research Scientist

Hui Jiang

Research Associate

Lynda Vuong

Scientific Research Lead

Daniel Barbakoff

Medical Student

Jie-Fu Chen

Assistant Attending Pathologist

Aaron Gillmor

Computational Biologist

Olvania-Danyca Hilaire

Senior Research Technician

David (Fengshen) Kuo

Bioinformatics Software Engineer

Andrea Lopez-Sanmiguel

Graduate Research Assistant

Nicole Rittenhouse

Research Technician

Alejandra Lopez Rojas

Research Technician

Chione Sylvester

Administrative Assistant

Ecenur Turkay

GSK Graduate Student

Ao Zhang

Urologic Oncology Fellow

Shweta Chavan

Senior Computational Biologist

Helen Won

Senior Computational Biologist

Amanda Sabel

Research Technician

Wenhuo Hu

Research Associate

Arijh Elfatih Elzein

Research Fellow

Keshia Pierre

Program Assistant

Manisha Rao

Research Fellow

Naryan Rustgi

Senior Research Technician

Naresh Vasani

Research Assistant

Andrew T. Lenis

Urology Fellow

Song Jiang

Fellow

Tripti Shrestha Bhattarai

Research Associate

Gamze Gokturk Ozcan

Senior Research Scientist

Carissa Chu

Visiting Investigator

Timothy Clinton

Urology Fellow

Jessica (Ziyu) Chen

Visiting Investigator

Florestan Koll

Visiting Investigator

Wesley Yip

Fellow

Dilara Akbulut

Research Fellow

Carlos Po

Research Technician

Kate Weiss

Research Technician

Benjamin Davelman

Research Technician

Mark Donoghue

Associate Director, CMO

Benjamin Freeman

Medical Student

Eduardo Ankur Mascareno

Research Technician

Adam Price

Bioinformatics Software Engineer

Allison Richards

Lead, CCS Analyst

Anne Marie Noronha

Bioinformatics Software Engineer

Sari Khaleel

Urology Fellow

Hyung Jun Woo

Senior Computational Biologist

Martina Bradic

Senior Computational Biologist

Samuel Tischfield

Senior Computational Biologist

Vasilisa Rudneva

Senior Computational Biologist

Vignesh Ravichandran

Senior Computational Biologist

Yixiao Gong

Lead, TEMPO Pipeline

Julian Agin-Liebes

Research Technician

Amber Ahmad

Research Technician

François Audenet

Urologic Oncology Fellow

Aditya Bagrodia

Urology Fellow

David Barron

Radiation Oncology Resident

Federica Catalanotti

Research Fellow

Eugene K. Cha

Assistant Attending, Urologic Oncology

Michael Cheng

Fellow

Shawn Dason

Urologic Oncology Fellow

Neil Desai

Resident in Radiation Oncology

Noah Friedman

Computational Biologist

Rebecca Hiner

Senior Technician

Joseph Hreiki

Research Fellow

Sumit Isharwal

Urologic Oncology Fellow

Manickam Janakiraman

Research Associate

Emmet Jordan

Fellow

Philip Kim

Clinical Research Fellow

Byron Lee

Urology Fellow

Qiang Li

Urology Fellow

Victor McPherson

Urology Fellow

Moriah Heller Nissan

OncoKB Scientist, Memorial Sloan Kettering Cancer Center, New York, NY

Alexandria Pinto

Computational Biologist

Ricardo Ramirez

Cornell University Graduate Student

John Sfakianos

Urology Fellow

Tara Soumerai

Assistant Attending, Gynecologic Medical Oncology Service

Brooke Sylvester

Research Fellow

Efsevia Vakiani

Assistant Attending Pathologist

Hannah Wise

Manager, Clinical Data at Flatiron Health, New York, NY

Feng Xing

Research Fellow

Alyssa Yee

Medical Student

Kai Zhang

Graduate Research Assistant

Li Kong

Research Fellow

Yogindra Persaud

Research Technician

Achievements

Member, American Society for Clinical Investigation (2011)
Louise and Allston Boyer Young Investigator Award for Basic Research, Memorial Sloan Kettering Cancer Center (2007)
Kimmel Scholar, Sidney Kimmel Foundation for Cancer Research (2007)
Career Development Award, American Society of Clinical Oncology (2002)
Young Investigator Award, American Society of Clinical (2001)

Doris Duke Translational Award, Doris Duke Foundation (2001)
Clinical Scholars Research Fellow, National Institutes of Health (2000)

Open Positions

To learn more about available postdoctoral opportunities, please visit our Career Center

To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs

Career Opportunities

Apply now

Postdoc Position in Preclinical and Translational Cancer Genomics and Therapeutics

Apply now

Get in Touch

solitd@mskcc.org

Lab Head Email
646-888-2641

For non-clinical issues only
646-422-4459

For patient-related issues
646-888-2649

Lab Phone

Disclosures

Members of the MSK Community often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community. These activities outside of MSK further our mission, provide productive collaborations, and promote the practical application of scientific discoveries.

MSK requires doctors, faculty members, and leaders to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public. Not all disclosed interests and relationships present conflicts of interest. MSK reviews all disclosed interests and relationships to assess whether a conflict of interest exists and whether formal COI management is needed.

David B. Solit discloses the following relationships and financial interests:

Antares Therapeutics, Inc.
Equity
BridgeBio Inc.
Professional Services and Activities
Corramedical, Inc.
Equity
Elsie Biotechnologies, Inc.
Equity; Professional Services and Activities
Fog Pharmaceuticals, Inc.
Professional Services and Activities
Fore Biotherapeutics
Equity; Professional Services and Activities

Function Oncology, Inc.
Equity; Professional Services and Activities
Meliora Therapeutics
Professional Services and Activities
Paige.AI, Inc.
Professional Services and Activities
Pfizer, Inc.
Professional Services and Activities
Pyramid Biosciences, Inc.
Equity; Professional Services and Activities
Scorpion Therapeutics, Inc.
Equity; Professional Services and Activities

The information published here is a complement to other publicly reported data and is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2024 through disclosure submission in spring 2025). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at ecoi@mskcc.org.

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