Human Oncology & Pathogenesis Program

The David Solit Lab

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Research

Pictured: David Solit
David B. Solit, MD
Co-Director, Marie-Josée & Henry R. Kravis Center for Molecular Oncology

Our research is based on the underlying hypothesis that the ability to inhibit an oncogenic pathway and block cancer growth will vary based on cell lineage and the complement of mutations within the tumor. To design rational therapeutic studies, we must define not only the spectrum of genetic changes within particular tumor types but also the mechanisms by which these alterations support tumor growth, survival, metastasis, and other hallmarks of cancer.

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Research Projects

The David Solit Lab

Featured News

Finding Clues in Genes of ‘Exceptional Responders’
Physician-scientist David Solit was interviewed about exceptional responders, patients who defy all expectations by responding dramatically to a drug t...
Event
A student asks a question at last year’s "Major Trends” seminar.
A Sneak Preview of Our Annual “Major Trends” Seminar Live Webcast
Every year, MSK gives high school students and their teachers the opportunity to learn about cutting-edge biomedical research from our scientists.
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Memorial Sloan Kettering is transforming our understanding and treatment of cancer in a myriad of ways.
Memorial Sloan Kettering Transforms Cancer Research and Care Delivery
Memorial Sloan Kettering’s vision is nothing less than to revolutionize the treatment of cancer. Learn about some of the ways we’re doing it.

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Publications Highlights

Xing F, Persaud Y, Pratilas CA, Taylor BS, Janakiraman M, She QB, Gallardo H, Liu C, Merghoub T, Hefter B, Dolgalev I, Viale A, Heguy A, De Stanchina E, Cobrinik D, Bollag G, Wolchok J, Houghton A, Solit DB. Concurrent loss of the PTEN and RB1 tumor suppressors attenuates RAF dependence in melanomas harboring (V600E)BRAF. Oncogene. 2012 Jan 26;31(4):446-57. doi: 10.1038/onc.2011.250. Epub 2011 Jul 4.

Poulikakos PI, Persaud Y, Janakiraman M, Kong X, Ng C, Moriceau G, Shi H, Atefi M, Titz B, Gabay MT, Salton M, Dahlman KB, Tadi M, Wargo JA, Flaherty KT, Kelley MC, Misteli T, Chapman PB, Sosman JA, Graeber TG, Ribas A, Lo RS, Rosen N, Solit DB. RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E). Nature. 2011 Nov 23;480(7377):387-90. doi: 10.1038/nature10662.

Hanrahan AJ, Schultz N, Westfal ML, Sakr RA, Giri DD, Scarperi S, Janakiraman M, Olvera N, Stevens EV, She QB, Aghajanian C, King TA, Stanchina Ed, Spriggs DR, Heguy A, Taylor BS, Sander C, Rosen N, Levine DA, Solit DB. Genomic complexity and AKT dependence in serous ovarian cancer. Cancer Discov. 2012 Jan;2(1):56-67. doi: 10.1158/2159-8290.CD-11-0170.

Misale S, Yaeger R, Hobor S, Scala E, Janakiraman M, Liska D, Valtorta E, Schiavo R, Buscarino M, Siravegna G, Bencardino K, Cercek A, Chen CT, Veronese S, Zanon C, Sartore-Bianchi A, Gambacorta M, Gallicchio M, Vakiani E, Boscaro V, Medico E, Weiser M, Siena S, Di Nicolantonio F, Solit D, Bardelli A. Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer. Nature. 2012 Jun 28;486(7404):532-6. doi: 10.1038/nature11156. 

Iyer G, Hanrahan AJ, Milowsky MI, Al-Ahmadie H, Scott SN, Janakiraman M, Pirun M, Sander C, Socci ND, Ostrovnaya I, Viale A, Heguy A, Peng L, Chan TA, Bochner B, Bajorin DF, Berger MF, Taylor BS, Solit DB. Genome sequencing identifies a basis for everolimus sensitivity. Science. 2012 Oct 12;338(6104):221. doi: 10.1126/science.1226344. Epub 2012 Aug 23.

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People

Pictured: David Solit

David B. Solit, MD

Co-Director, Marie-Josée & Henry R. Kravis Center for Molecular Oncology

  • Physician-scientist David Solit studies human oncology and pathogenesis, genomics, oncogenes and tumor suppressors, cancer therapeutics, and clinical trials.
  • MD, University of Pennsylvania
solitd@mskcc.org
Email Address
View physician profile
Physician profile

Members

Alexis M. Jones, MS
Alexis M. Jones

Research Lab Manager

Aphrothiti Hanrahan, PhD
Aphrothiti Hanrahan

Assistant Lab Member

Gopa Iyer, MD
Gopa Iyer

Assistant Attending, Genitourinary Oncology Service

Kwanghee Kim
Kwanghee Kim

Assistant Attending Biologist

Sizhi Paul Gao
Paul (Sizhi) Gao

Scientific Research Lead

James Rodrigues

GSK Graduate Student

Josie (Jiaqian) Luo

Weill Cornell BCMB Graduate Student

Michelle (Xinran) Tang

Weill Cornell Graduate Student

Jacob Tallman

Urologic Oncology Fellow

Syed Muneeb Alam

Fellow

Jordan Eichholz

Computational Biologist I

Hikmat A. Al-Ahmadie, MD
Hikmat A. Al-Ahmadie

Associate Attending Pathologist, Memorial Hospital

Cansu Yol

Senior Research Scientist

Merve Basar

Senior Research Scientist

Jie-Fu Chen

Assistant Attending Pathologist

Olvania Danyca Hilaire

Senior Research Technician

Alejandra Lopez Rojas

Research Technician

Chione Sylvester
Chione Sylvester

Administrative Assistant

Ecenur Turkay

GSK Graduate Student

Ao Zhang

Urologic Oncology Fellow

Lab Alumni
Shweta Chavan
Shweta Chavan

Senior Computational Biologist

Helen Won, MS
Helen Won

Senior Computational Biologist

Amanda Sabel

Research Technician

Wenhuo Hu, PhD
Wenhuo Hu

Research Associate

Arijh Elfatih Elzein

Research Fellow

Keshia Pierre

Program Assistant

Manisha Rao

Research Fellow

Naryan Rustgi

Senior Research Technician

Naresh Vasani
Naresh Vasani

Research Assistant

Andrew T. Lenis

Urology Fellow

Song Jiang

Fellow

Tripti Shrestha Bhattarai, PhD
Tripti Shrestha Bhattarai

Research Associate

Gamze Gokturk Ozcan

Senior Research Scientist

Carissa Chu

Visiting Investigator

Timothy Clinton

Urology Fellow

Jessica (Ziyu) Chen

Visiting Investigator

Florestan Koll
Florestan Koll

Visiting Investigator

Wesley Yip

Fellow

Dilara Akbulut

Research Fellow

Abraham Ari Hakimi
Abraham Ari Hakimi

Assistant Attending, Department of Surgery

Carlos Po

Research Technician

Doris Zheng

Research Technician

Hui Jiang
Hui Jiang

Research Scholar

Kate Weiss
Kate Weiss

Research Technician

Benjamin Davelman

Research Technician

Lynda Vuong

Senior Research Scientist

Mark Donoghue, PhD
Mark Donoghue

Associate Director, CMO

Benjamin Freeman

Medical Student

Eduardo Ankur Mascareno

Research Technician

Adam Price

Bioinformatics Software Engineer

Allison Richards, Computational Biologist II
Allison Richards

Lead, CCS Analyst

Anne Marie Noronha
Anne Marie Noronha

Bioinformatics Software Engineer

Sari Khaleel

Urology Fellow

Hyung Jun Woo
Hyung Jun Woo

Senior Computational Biologist

Martina Bradic
Martina Bradic

Senior Computational Biologist

Samuel Tischfield
Samuel Tischfield

Senior Computational Biologist

Vasilisa Rudneva
Vasilisa Rudneva

Senior Computational Biologist

Vignesh Ravichandran

Senior Computational Biologist

Yixiao Gong
Yixiao Gong

Lead, TEMPO Pipeline

Julian Agin-Liebes
Julian Agin-Liebes

Research Technician

Amber Ahmad

Research Technician

François Audenet
François Audenet

Urologic Oncology Fellow

Aditya Bagrodia
Aditya Bagrodia

Urology Fellow

Daniel Barbakoff

Medical Student

David Barron, MD, PhD
David Barron

Radiation Oncology Resident

Federica Catalanotti, PhD
Federica Catalanotti

Research Fellow

Eugene K. Cha, MD
Eugene K. Cha

Assistant Attending, Urologic Oncology

Michael Cheng

Fellow

Shawn Dason, Urologic Oncology Fellow
Shawn Dason

Urologic Oncology Fellow

Neil Desai, MD, MHS
Neil Desai

Resident in Radiation Oncology

Noah Friedman, Computational Biologist II
Noah Friedman

Computational Biologist

Rebecca Hiner

Senior Technician

Joseph Hreiki, MD
Joseph Hreiki

Research Fellow

Sumit Isharwal
Sumit Isharwal

Urologic Oncology Fellow

Manickam Janakiraman, PhD
Manickam Janakiraman

Research Associate

Emmet Jordan
Emmet Jordan

Fellow

Philip Kim, MD
Philip Kim

Clinical Research Fellow

David (Fengshen) Kuo

Bioinformatics Engineer

Byron Lee

Urology Fellow

Qiang Li
Qiang Li

Urology Fellow

Andrea Lopez-Sanmiguel

Graduate Research Assistant

Victor McPherson

Urology Fellow

Moriah Heller Nissan, PhD
Moriah Heller Nissan

OncoKB Scientist, Memorial Sloan Kettering Cancer Center, New York, NY

Alexandria Pinto

Computational Biologist

Ricardo Ramirez
Ricardo Ramirez

Cornell University Graduate Student

Nicole Rittenhouse

Research Technician

John Sfakianos
John Sfakianos

Urology Fellow

Tara Soumerai
Tara Soumerai

Assistant Attending, Gynecologic Medical Oncology Service

Brooke Sylvester, PhD
Brooke Sylvester

Research Fellow

Efsevia Vakiani, MD, PhD
Efsevia Vakiani

Assistant Attending Pathologist

Hannah Wise
Hannah Wise

Lead Clinical Data Analyst at Flatiron Health, New York, NY

Feng Xing, PhD
Feng Xing

Research Fellow

Alyssa Yee
Alyssa Yee

Medical Student

Kai Zhang

Graduate Research Assistant

Li Kong, PhD
Li Kong

Research Fellow

Yogindra Persaud
Yogindra Persaud

Research Technician

Lab Affiliations

Achievements

  • Member, American Society for Clinical Investigation (2011)
  • Louise and Allston Boyer Young Investigator Award for Basic Research, Memorial Sloan Kettering Cancer Center (2007)
  • Kimmel Scholar, Sidney Kimmel Foundation for Cancer Research (2007)
  • Career Development Award, American Society of Clinical Oncology (2002)
  • Young Investigator Award, American Society of Clinical (2001)
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  • Doris Duke Translational Award, Doris Duke Foundation (2001)
  • Clinical Scholars Research Fellow, National Institutes of Health (2000)

Open Positions

To learn more about available postdoctoral opportunities, please visit our Career Center

To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs

Career Opportunities

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Postdoc Position in Preclinical and Translational Cancer Genomics and Therapeutics

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Get in Touch

Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

David B. Solit discloses the following relationships and financial interests:

  • American Association for Cancer Research
    Professional Services and Activities
  • BridgeBio Inc.
    Professional Services and Activities
  • Elsie Biotechnologies, Inc.
    Equity; Professional Services and Activities
  • Fog Pharmaceuticals, Inc.
    Professional Services and Activities
  • Fore Biotherapeutics
    Equity; Professional Services and Activities
  • Function Oncology, Inc.
    Equity; Professional Services and Activities
  • Paige.AI, Inc.
    Professional Services and Activities
  • Pfizer, Inc.
    Professional Services and Activities
  • Pyramid Biosciences, Inc.
    Equity; Professional Services and Activities
  • Rain Therapeutics Inc.
    Professional Services and Activities
  • Scorpion Therapeutics, Inc.
    Equity; Professional Services and Activities
  • Vividion Therapeutics
    Equity

The information published here is a complement to other publicly reported data and is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2023 through disclosure submission in spring 2024). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at ecoi@mskcc.org.


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